A
Allan Bradley
Researcher at Wellcome Trust Sanger Institute
Publications - 385
Citations - 81969
Allan Bradley is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 127, co-authored 379 publications receiving 77492 citations. Previous affiliations of Allan Bradley include Howard Hughes Medical Institute & University of Texas MD Anderson Cancer Center.
Papers
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Journal ArticleDOI
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair
Prolla Ta,Sean M. Baker,A. C. Harris,J.-L. Tsao,Xiang Yao,Bronner Ce,Binhai Zheng,Binhai Zheng,M. Gordon,J. Reneker,Norman Arnheim,Darryl Shibata,Allan Bradley,R. M. Liskay +13 more
TL;DR: The results suggest that a general increase in replication errors may not be sufficient for intestinal tumour formation and that these genes share overlapping, but not identical functions.
Journal ArticleDOI
Agouti C57BL/6N embryonic stem cells for mouse genetic resources.
Stephen J. Pettitt,Qi Liang,Xin Y. Rairdan,Jennifer L. Moran,Jennifer L. Moran,Haydn M. Prosser,David R. Beier,Kevin C K Lloyd,Kevin C K Lloyd,Allan Bradley,William C. Skarnes +10 more
TL;DR: These cells provide a robust foundation for large-scale mouse knockout programs that aim to provide a public resource of targeted mutations in the C57BL/6 genetic background.
Journal ArticleDOI
Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue.
Huiling Liang,Qin Chen,Andrew H. Coles,Stephen J. Anderson,German Pihan,Allan Bradley,Rachel M. Gerstein,Roland Jurecic,Stephen N. Jones +8 more
TL;DR: It is demonstrated that Wnt5a signals through the noncanonical Wnt/Ca++ pathway to suppress cyclin D1 expression and negatively regulate B cell proliferation in a cell-autonomous manner and suppresses hematopoietic malignancies.
Book ChapterDOI
Gene targeting in embryonic stem cells
Journal ArticleDOI
Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments
TL;DR: Two Hoxb-4 (Hox-2.6) mutations were introduced into the mouse germline and caused two obvious skeletal changes: a partial homeotic transformation of the second cervical vertebra from axis to atlas and a defective morphogenesis of the sternum.