A
Allan Bradley
Researcher at Wellcome Trust Sanger Institute
Publications - 385
Citations - 81969
Allan Bradley is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 127, co-authored 379 publications receiving 77492 citations. Previous affiliations of Allan Bradley include Howard Hughes Medical Institute & University of Texas MD Anderson Cancer Center.
Papers
More filters
Journal ArticleDOI
Transposon-mediated genome manipulation in vertebrates.
Zoltán Ivics,Meng Amy Li,Lajos Mátés,Jef D. Boeke,Andras Nagy,Allan Bradley,Zsuzsanna Izsvák,Zsuzsanna Izsvák +7 more
TL;DR: An overview of transposon-based methods used in vertebrate model organisms with an emphasis on the mouse system is provided and the most important considerations concerning genetic applications of thetransposon systems are highlighted.
Journal ArticleDOI
Hyperuricemia and urate nephropathy in urate oxidase-deficient mice
Xiangwei Wu,Maki Wakamiya,Sukeshi Vaishnav,Robert S. Geske,Charles A. Montgomery,Peter B. Jones,Allan Bradley,Charles T. Caskey +7 more
TL;DR: More than half of the mutant mice died before 4 weeks of age, indicating that urate oxidase is essential in mice, and these mutant mice may also serve as animal models for hyperuricemia and its related nephropathy in humans.
Journal Article
Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance.
TL;DR: The Rb knock out mouse strain provides a unique model for addressing tissue-specific tumor predisposition by inactivation of a ubiquitously expressed tumor suppressor gene.
Journal ArticleDOI
Chromosomal Transposition of a Tc1/Mariner-Like Element in Mouse Embryonic Stem Cells
TL;DR: The chromosomal transposition of the Sleeping Beauty (SB) element in mouse embryonic stem cells is reported, providing evidence that it can be used as an in vivo mutagen in mice.
Journal ArticleDOI
Effects of genetic background on tumorigenesis in p53-deficient mice
Lawrence A. Donehower,Michele Harvey,Michele Harvey,Hannes Vogel,Mark J. McArthur,Charles A. Montgomery,Sang H. Park,Timothy C. Thompson,Richard J. Ford,Allan Bradley +9 more
TL;DR: The high incidence of early‐onset lymphomas in the p53‐nullizygous mice makes these animals a good lymphoma model, whereas the heterozygous mice may be a useful model for Li‐Fraumeni syndrome, a human inherited cancer predisposition.