A
Amanda L. Tapia
Researcher at University of North Carolina at Chapel Hill
Publications - 15
Citations - 335
Amanda L. Tapia is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Genome-wide association study & Autism spectrum disorder. The author has an hindex of 3, co-authored 11 publications receiving 173 citations.
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Journal ArticleDOI
Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations
Madeline H. Kowalski,Huijun Qian,Ziyi Hou,Jonathan D. Rosen,Amanda L. Tapia,Yue Shan,Deepti Jain,Maria Argos,Donna K. Arnett,Christy L. Avery,Kathleen C. Barnes,Lewis C. Becker,Stephanie A. Bien,Joshua C. Bis,John Blangero,Eric Boerwinkle,Donald W. Bowden,Steve Buyske,Jianwen Cai,Michael H. Cho,Michael H. Cho,Seung Hoan Choi,Hélène Choquet,L. Adrienne Cupples,Mary Cushman,Michelle Daya,Paul S. de Vries,Patrick T. Ellinor,Patrick T. Ellinor,Nauder Faraday,Myriam Fornage,Stacey Gabriel,Santhi K. Ganesh,Misa Graff,Namrata Gupta,Jiang He,Susan R. Heckbert,Susan R. Heckbert,Bertha Hidalgo,Chani J. Hodonsky,Marguerite R. Irvin,Andrew D. Johnson,Eric Jorgenson,Robert C. Kaplan,Sharon L.R. Kardia,Tanika N. Kelly,Charles Kooperberg,Jessica Lasky-Su,Jessica Lasky-Su,Ruth J. F. Loos,Steven A. Lubitz,Steven A. Lubitz,Rasika A. Mathias,Caitlin P. McHugh,Courtney G. Montgomery,Jee-Young Moon,Alanna C. Morrison,Nicholette D. Palmer,Nathan Pankratz,George Papanicolaou,Juan M. Peralta,Patricia A. Peyser,Stephen S. Rich,Jerome I. Rotter,Edwin K. Silverman,Edwin K. Silverman,Jennifer A. Smith,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Kent D. Taylor,Timothy A. Thornton,Hemant K. Tiwari,Russell P. Tracy,Tao Wang,Scott T. Weiss,Scott T. Weiss,Lu-Chen Weng,Kerri L. Wiggins,James G. Wilson,Lisa R. Yanek,Sebastian Zöllner,Kari E. North,Paul L. Auer,Laura M. Raffield,Alex P. Reiner,Yun Li +86 more
TL;DR: It is demonstrated that using TOPMed sequencing data as the imputation reference panel improves genotypes into admixed African and Hispanic/Latino samples with genome-wide genotyping array data, which subsequently enhanced gene-mapping power for complex traits.
Journal ArticleDOI
Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study.
David S. Knopman,Rebecca F. Gottesman,A. Richey Sharrett,Amanda L. Tapia,Sonia DavisThomas,B. Gwen Windham,Laura H. Coker,Andrea L.C. Schneider,Alvaro Alonso,Josef Coresh,Marilyn S. Albert,Thomas H. Mosley +11 more
TL;DR: The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood.
Posted ContentDOI
Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations
Madeline H. Kowalski,Huijun Qian,Ziyi Hou,Jonathan D. Rosen,Amanda L. Tapia,Yue Shan,Deepti Jain,Maria Argos,Donna K. Arnett,Christy L. Avery,Kathleen C. Barnes,Lewis C. Becker,Stephanie A. Bien,Joshua C. Bis,John Blangero,Eric Boerwinkle,Donald W. Bowden,Steve Buyske,Jianwen Cai,Michael H. Cho,Michael H. Cho,Seung Hoan Choi,Hélène Choquet,L. Adrienne Cupples,Mary Cushman,Michelle Daya,Paul S. de Vries,Patrick T. Ellinor,Patrick T. Ellinor,Nauder Faraday,Myriam Fornage,Stacey Gabriel,Santhi K. Ganesh,Misa Graff,Namrata Gupta,Jiang He,Susan R. Heckbert,Susan R. Heckbert,Bertha Hidalgo,Chani J. Hodonsky,Marguerite R. Irvin,Andrew D. Johnson,Eric Jorgenson,Robert C. Kaplan,Sharon L.R. Kardia,Tanika N. Kelly,Charles Kooperberg,Jessica Lasky-Su,Jessica Lasky-Su,Ruth J. F. Loos,Steven A. Lubitz,Steven A. Lubitz,Rasika A. Mathias,Caitlin P. McHugh,Courtney G. Montgomery,Jee-Young Moon,Alanna C. Morrison,Nicholette D. Palmer,Nathan Pankratz,George Papanicolaou,Juan M. Peralta,Patricia A. Peyser,Stephen S. Rich,Jerome I. Rotter,Edwin K. Silverman,Edwin K. Silverman,Jennifer A. Smith,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Kent D. Taylor,Timothy A. Thornton,Hemant K. Tiwari,Russell P. Tracy,Tao Wang,Scott T. Weiss,Scott T. Weiss,Lu-Chen Weng,Kerri L. Wiggins,James G. Wilson,Lisa R. Yanek,Sebastian Zöllner,Kari E. North,Paul L. Auer,Laura M. Raffield,Alex P. Reiner,Yun Li +86 more
TL;DR: It is demonstrated that using TOPMed sequencing data as the imputation reference panel improves genotype imputation quality in these populations, which subsequently enhances gene-mapping power for complex traits and highlights the utility of TOPMed imputations for identification of novel associations between rare variants and complex traits not previously detected in similar sized genome-wide studies of under-represented African and Hispanic/Latino populations.
Journal ArticleDOI
MRLocus: Identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity.
Anqi Zhu,Nana Matoba,Emmaleigh Wilson,Amanda L. Tapia,Yun Li,Joseph G. Ibrahim,Jason L. Stein,Michael I. Love +7 more
TL;DR: In this article, Love et al. introduced a new statistical method, MRLocus, for Bayesian estimation of the gene-to-trait effect from eQTL and GWAS summary data for loci with evidence of allelic heterogeneity, that is, containing multiple causal variants.
Posted ContentDOI
MRLocus: identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity
Anqi Zhu,Nana Matoba,Emmaleigh Wilson,Amanda L. Tapia,Yun Li,Joseph G. Ibrahim,Jason L. Stein,Michael I. Love +7 more
TL;DR: It is found that MRLocus’ estimation of the causal effect across eQTLs within a locus provides useful information for determining how perturbation of gene expression or individual regulatory elements will affect downstream traits.