Misa Graff

TL;DR: It is demonstrated that using TOPMed sequencing data as the imputation reference panel improves genotypes into admixed African and Hispanic/Latino samples with genome-wide genotyping array data, which subsequently enhanced gene-mapping power for complex traits.

TL;DR: The results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution, and highlight the importance of accounting for environment in genetic analyses.

TL;DR: This study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.

TL;DR: In this article, the authors use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of heterozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment.

TL;DR: Improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying foundations for functional investigations.