J
Juan M. Peralta
Researcher at University of Texas at Austin
Publications - 93
Citations - 2610
Juan M. Peralta is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Genome-wide association study & Gene. The author has an hindex of 24, co-authored 78 publications receiving 1757 citations. Previous affiliations of Juan M. Peralta include University of Texas at Brownsville & Menzies Research Institute.
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Journal ArticleDOI
Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
Alexander G. Bick,Joshua S. Weinstock,Satish K. Nandakumar,Satish K. Nandakumar,Charles P. Fulco,Charles P. Fulco,Erik L. Bao,Erik L. Bao,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Mindy D. Szeto,Xiaotian Liao,Xiaotian Liao,Matthew Leventhal,Joseph Nasser,Kyle Chang,Cecelia A. Laurie,Bala Bharathi Burugula,Christopher J. Gibson,Amy E. Lin,Margaret A. Taub,François Aguet,Kristin G. Ardlie,Braxton D. Mitchell,Braxton D. Mitchell,Kathleen C. Barnes,Kathleen C. Barnes,Arden Moscati,Myriam Fornage,Susan Redline,Susan Redline,Susan Redline,Bruce M. Psaty,Edwin K. Silverman,Edwin K. Silverman,Scott T. Weiss,Scott T. Weiss,Nicholette D. Palmer,Ramachandran S. Vasan,Esteban G. Burchard,Sharon L.R. Kardia,Jiang He,Robert C. Kaplan,Robert C. Kaplan,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Donna K. Arnett,David A. Schwartz,Adolfo Correa,Mariza de Andrade,Xiuqing Guo,Barbara A. Konkle,Brian Custer,Juan M. Peralta,Hongsheng Gui,Deborah A. Meyers,Stephen T. McGarvey,Ida Yii-Der Chen,M. Benjamin Shoemaker,Patricia A. Peyser,Jai G. Broome,Stephanie M. Gogarten,Fei Fei Wang,Quenna Wong,May E. Montasser,Michelle Daya,Eimear E. Kenny,Kari E. North,Lenore J. Launer,Brian E. Cade,Brian E. Cade,Joshua C. Bis,Michael H. Cho,Michael H. Cho,Jessica Lasky-Su,Jessica Lasky-Su,Donald W. Bowden,L. Adrienne Cupples,Angel C.Y. Mak,Lewis C. Becker,Jennifer A. Smith,Tanika N. Kelly,Stella Aslibekyan,Susan R. Heckbert,Susan R. Heckbert,Hemant K. Tiwari,Ivana V. Yang,John A. Heit,Steven A. Lubitz,Steven A. Lubitz,Jill M. Johnsen,Joanne E. Curran,Sally E. Wenzel,Daniel E. Weeks,Dabeeru C. Rao,Dawood Darbar,Jee-Young Moon,Russell P. Tracy,Erin J Buth,Nicholas Rafaels,Ruth J. F. Loos,Peter Durda,Yongmei Liu,Lifang Hou,Jiwon Lee,Priyadarshini Kachroo,Priyadarshini Kachroo,Barry I. Freedman,Daniel Levy,Lawrence F. Bielak,James E. Hixson,James S. Floyd,Eric A. Whitsel,Patrick T. Ellinor,Patrick T. Ellinor,Marguerite R. Irvin,Tasha E. Fingerlin,Laura M. Raffield,Sebastian M. Armasu,Marsha M. Wheeler,Ester Cerdeira Sabino,John Blangero,L. Keoki Williams,Bruce D. Levy,Bruce D. Levy,Wayne Huey-Herng Sheu,Dan M. Roden,Eric Boerwinkle,Eric Boerwinkle,JoAnn E. Manson,JoAnn E. Manson,Rasika A. Mathias,Pinkal Desai,Kent D. Taylor,Andrew D. Johnson,Paul L. Auer,Charles Kooperberg,Cathy C. Laurie,Thomas W. Blackwell,Albert V. Smith,Hongyu Zhao,Ethan M. Lange,Leslie A. Lange,Stephen S. Rich,Jerome I. Rotter,James G. Wilson,James G. Wilson,Paul Scheet,Jacob O. Kitzman,Eric S. Lander,Eric S. Lander,Eric S. Lander,Jesse M. Engreitz,Jesse M. Engreitz,Benjamin L. Ebert,Alexander P. Reiner,Alexander P. Reiner,Siddhartha Jaiswal,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Vijay G. Sankaran,Vijay G. Sankaran,Sekar Kathiresan,Pradeep Natarajan,Pradeep Natarajan +165 more
TL;DR: Analysis of high-coverage whole-genome sequences from 97,691 participants of diverse ancestries in the National Heart, Lung, and Blood Institute Trans-omics for Precision Medicine programme enables simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells.
Journal ArticleDOI
Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families.
David C. Glahn,Laura Almasy,Marcela Barguil,Elizabeth Hare,Juan M. Peralta,Jack W. Kent,Albana M Dassori,Javier Contreras,Adriana Pacheco,Nuria Lanzagorta,Humberto Nicolini,Henriette Raventós,Michael Escamilla +12 more
TL;DR: This large-scale extended pedigree study of cognitive functioning in bipolar disorder identifies measures of processing speed, working memory, and declarative (facial) memory as candidate endophenotypes for bipolar disorder.
Journal ArticleDOI
Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations
Madeline H. Kowalski,Huijun Qian,Ziyi Hou,Jonathan D. Rosen,Amanda L. Tapia,Yue Shan,Deepti Jain,Maria Argos,Donna K. Arnett,Christy L. Avery,Kathleen C. Barnes,Lewis C. Becker,Stephanie A. Bien,Joshua C. Bis,John Blangero,Eric Boerwinkle,Donald W. Bowden,Steve Buyske,Jianwen Cai,Michael H. Cho,Michael H. Cho,Seung Hoan Choi,Hélène Choquet,L. Adrienne Cupples,Mary Cushman,Michelle Daya,Paul S. de Vries,Patrick T. Ellinor,Patrick T. Ellinor,Nauder Faraday,Myriam Fornage,Stacey Gabriel,Santhi K. Ganesh,Misa Graff,Namrata Gupta,Jiang He,Susan R. Heckbert,Susan R. Heckbert,Bertha Hidalgo,Chani J. Hodonsky,Marguerite R. Irvin,Andrew D. Johnson,Eric Jorgenson,Robert C. Kaplan,Sharon L.R. Kardia,Tanika N. Kelly,Charles Kooperberg,Jessica Lasky-Su,Jessica Lasky-Su,Ruth J. F. Loos,Steven A. Lubitz,Steven A. Lubitz,Rasika A. Mathias,Caitlin P. McHugh,Courtney G. Montgomery,Jee-Young Moon,Alanna C. Morrison,Nicholette D. Palmer,Nathan Pankratz,George Papanicolaou,Juan M. Peralta,Patricia A. Peyser,Stephen S. Rich,Jerome I. Rotter,Edwin K. Silverman,Edwin K. Silverman,Jennifer A. Smith,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Kent D. Taylor,Timothy A. Thornton,Hemant K. Tiwari,Russell P. Tracy,Tao Wang,Scott T. Weiss,Scott T. Weiss,Lu-Chen Weng,Kerri L. Wiggins,James G. Wilson,Lisa R. Yanek,Sebastian Zöllner,Kari E. North,Paul L. Auer,Laura M. Raffield,Alex P. Reiner,Yun Li +86 more
TL;DR: It is demonstrated that using TOPMed sequencing data as the imputation reference panel improves genotypes into admixed African and Hispanic/Latino samples with genome-wide genotyping array data, which subsequently enhanced gene-mapping power for complex traits.
Journal ArticleDOI
Genetic Analysis Workshop 17 mini-exome simulation.
Laura Almasy,Thomas D. Dyer,Juan M. Peralta,Jack W. Kent,Jac Charlesworth,Joanne E. Curran,John Blangero +6 more
TL;DR: The data set simulated for Genetic Analysis Workshop 17 was designed to mimic a subset of data that might be produced in a full exome screen for a complex disorder and related risk factors in order to permit workshop participants to investigate issues of study design and statistical genetic analysis.
Journal ArticleDOI
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
Xihao Li,Zilin Li,Hufeng Zhou,Sheila M. Gaynor,Yaowu Liu,Han Chen,Ryan Sun,Rounak Dey,Donna K. Arnett,Stella Aslibekyan,Christie M. Ballantyne,Lawrence F. Bielak,John Blangero,Eric Boerwinkle,Eric Boerwinkle,Donald W. Bowden,Jai G. Broome,Matthew P. Conomos,Adolfo Correa,L. Adrienne Cupples,Joanne E. Curran,Barry I. Freedman,Xiuqing Guo,George Hindy,Marguerite R. Irvin,Sharon L.R. Kardia,Sekar Kathiresan,Alyna T. Khan,Charles Kooperberg,Cathy C. Laurie,X. Shirley Liu,Michael C. Mahaney,Ani Manichaikul,Lisa W. Martin,Rasika A. Mathias,Stephen T. McGarvey,Braxton D. Mitchell,Braxton D. Mitchell,May E. Montasser,Jill Moore,Alanna C. Morrison,Jeffrey R. O'Connell,Nicholette D. Palmer,Akhil Pampana,Akhil Pampana,Juan M. Peralta,Patricia A. Peyser,Bruce M. Psaty,Bruce M. Psaty,Susan Redline,Susan Redline,Susan Redline,Kenneth Rice,Stephen S. Rich,Jennifer A. Smith,Hemant K. Tiwari,Michael Y. Tsai,Ramachandran S. Vasan,Fei Fei Wang,Daniel E. Weeks,Zhiping Weng,James G. Wilson,James G. Wilson,Lisa R. Yanek,Benjamin M. Neale,Benjamin M. Neale,Shamil R. Sunyaev,Shamil R. Sunyaev,Shamil R. Sunyaev,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Jerome I. Rotter,Cristen J. Willer,Gina M. Peloso,Pradeep Natarajan,Pradeep Natarajan,Xihong Lin,Xihong Lin +77 more
TL;DR: STAAR is a powerful rare variant association test that incorporates variant functional categories and complementary functional annotations using a dynamic weighting scheme based on annotation principal components and is scalable for analyzing large whole-genome sequencing studies.