Jonathan D. Rosen

TL;DR: The results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation.

TL;DR: The clinical significance and predictive value of trans-ethnic variants in multiple populations are explored, genetic architecture and the effect of natural selection on these blood phenotypes between populations are compared and the value of a more global representation of populations in genetic studies is highlighted.

TL;DR: It is demonstrated that using TOPMed sequencing data as the imputation reference panel improves genotypes into admixed African and Hispanic/Latino samples with genome-wide genotyping array data, which subsequently enhanced gene-mapping power for complex traits.

TL;DR: These results show the power of large-scale blood cell GWAS to interrogate clinically meaningful variants across the full allelic spectrum of human variation.

TL;DR: It is shown that chromatin interactions underlie several aspects of gene regulation, with transposable elements and disease-associated variants enriched at distal interacting regions in a cell-type-specific manner.