S
Stephanie A. Bien
Researcher at Fred Hutchinson Cancer Research Center
Publications - 61
Citations - 3001
Stephanie A. Bien is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 18, co-authored 51 publications receiving 1943 citations.
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Journal ArticleDOI
Genetic analyses of diverse populations improves discovery for complex traits
Genevieve L. Wojcik,Mariaelisa Graff,Katherine K. Nishimura,Ran Tao,Jeffrey Haessler,Christopher R. Gignoux,Christopher R. Gignoux,Heather M. Highland,Yesha Patel,Elena P. Sorokin,Christy L. Avery,Gillian M. Belbin,Stephanie A. Bien,Iona Cheng,Sinead Cullina,Chani J. Hodonsky,Yao Hu,Laura M. Huckins,Janina M. Jeff,Anne E. Justice,Jonathan M. Kocarnik,Unhee Lim,Bridget M Lin,Yingchang Lu,Sarah C. Nelson,Sungshim L. Park,Hannah Poisner,Michael Preuss,Melissa A. Richard,Claudia Schurmann,Claudia Schurmann,Veronica Wendy Setiawan,Alexandra Sockell,Karan Vahi,Marie Verbanck,Abhishek Vishnu,Ryan W. Walker,Kristin L. Young,Niha Zubair,Victor Acuña-Alonso,José Luis Ambite,Kathleen C. Barnes,Eric Boerwinkle,Erwin P. Bottinger,Erwin P. Bottinger,Carlos Bustamante,Christian Caberto,Samuel Canizales-Quinteros,Matthew P. Conomos,Ewa Deelman,Ron Do,Kimberly F. Doheny,Lindsay Fernández-Rhodes,Lindsay Fernández-Rhodes,Myriam Fornage,Benyam Hailu,Gerardo Heiss,Brenna M. Henn,Lucia A. Hindorff,Rebecca D. Jackson,Cecelia A. Laurie,Cathy C. Laurie,Yuqing Li,Yuqing Li,Danyu Lin,Andrés Moreno-Estrada,Girish N. Nadkarni,Paul Norman,Loreall Pooler,Alexander P. Reiner,Jane Romm,Chiara Sabatti,Karla Sandoval,Xin Sheng,Eli A. Stahl,Daniel O. Stram,Timothy A. Thornton,Christina L. Wassel,Lynne R. Wilkens,Cheryl A. Winkler,Sachi Yoneyama,Steven Buyske,Christopher A. Haiman,Charles Kooperberg,Loic Le Marchand,Ruth J. F. Loos,Tara C. Matise,Kari E. North,Ulrike Peters,Eimear E. Kenny,Christopher S. Carlson +90 more
TL;DR: The value of diverse, multi-ethnic participants in large-scale genomic studies is demonstrated and evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts and insights into clinical implications are shown.
Journal ArticleDOI
Discovery of common and rare genetic risk variants for colorectal cancer
Jeroen R. Huyghe,Stephanie A. Bien,Tabitha A. Harrison,Hyun Min Kang,Sai Chen,Stephanie L. Schmit,David V. Conti,Conghui Qu,Jihyoun Jeon,Christopher K. Edlund,Peyton Greenside,Michael Wainberg,Fredrick R. Schumacher,Joshua D. Smith,David M. Levine,Sarah C. Nelson,Nasa Sinnott-Armstrong,Demetrius Albanes,M. Henar Alonso,Kristin E. Anderson,Coral Arnau-Collell,Volker Arndt,Christina Bamia,Barbara L. Banbury,John A. Baron,Sonja I. Berndt,Stéphane Bézieau,D. Timothy Bishop,Juergen Boehm,Heiner Boeing,Hermann Brenner,Stefanie Brezina,Stephan Buch,Daniel D. Buchanan,Daniel D. Buchanan,Andrea N. Burnett-Hartman,Katja Butterbach,Bette J. Caan,Peter T. Campbell,Christopher S. Carlson,Christopher S. Carlson,Sergi Castellví-Bel,Andrew T. Chan,Andrew T. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Stephen J. Chanock,Maria Dolores Chirlaque,Sang-Hee Cho,Charles M. Connolly,Amanda J. Cross,Katarina Cuk,Keith R. Curtis,Albert de la Chapelle,Kimberly F. Doheny,David Duggan,Douglas F. Easton,Sjoerd G. Elias,Faye Elliott,Dallas R. English,Dallas R. English,Edith J. M. Feskens,Jane C. Figueiredo,Jane C. Figueiredo,Rocky Fischer,Liesel M. FitzGerald,Liesel M. FitzGerald,David Forman,Manish Gala,Steven Gallinger,W. James Gauderman,Graham G. Giles,Graham G. Giles,Elizabeth M. Gillanders,Jian Gong,Phyllis J. Goodman,William M. Grady,John S. Grove,Andrea Gsur,Marc J. Gunter,Robert W. Haile,Jochen Hampe,Heather Hampel,Sophia Harlid,Richard B. Hayes,Philipp Hofer,Michael Hoffmeister,John L. Hopper,John L. Hopper,Wan-Ling Hsu,Wen Yi Huang,Thomas J. Hudson,David J. Hunter,David J. Hunter,Gemma Ibáñez-Sanz,Gregory Idos,Roxann G. Ingersoll,Rebecca D. Jackson,Eric J. Jacobs,Mark A. Jenkins,Amit Joshi,Corinne E. Joshu,Temitope O. Keku,Timothy J. Key,Hyeong Rok Kim,Emiko Kobayashi,Laurence N. Kolonel,Charles Kooperberg,Tilman Kühn,Sébastien Küry,Sun-Seog Kweon,Susanna C. Larsson,Cecelia A. Laurie,Loic Le Marchand,Suzanne M. Leal,Soo-Chin Lee,Flavio Lejbkowicz,Mathieu Lemire,Christopher I. Li,Li Li,Wolfgang Lieb,Yi Lin,Annika Lindblom,Noralane M. Lindor,Hua Ling,Tin Louie,Satu Männistö,Sanford D. Markowitz,Vicente Martín,Giovanna Masala,Caroline McNeil,Marilena Melas,Roger L. Milne,Roger L. Milne,Lorena Moreno,Neil Murphy,Robin Myte,Alessio Naccarati,Polly A. Newcomb,Polly A. Newcomb,Kenneth Offit,Kenneth Offit,Shuji Ogino,Shuji Ogino,N. Charlotte Onland-Moret,Barbara Pardini,Patrick S. Parfrey,Rachel Pearlman,Vittorio Perduca,Vittorio Perduca,Paul D.P. Pharoah,Mila Pinchev,Elizabeth A. Platz,Ross L. Prentice,Elizabeth W. Pugh,Leon Raskin,Gad Rennert,Gad Rennert,Hedy S. Rennert,Hedy S. Rennert,Elio Riboli,Miguel Rodríguez-Barranco,Jane Romm,Lori C. Sakoda,Lori C. Sakoda,Clemens Schafmayer,Robert E. Schoen,Daniela Seminara,Mitul Shah,Tameka Shelford,Min-Ho Shin,Katerina Shulman,Sabina Sieri,Martha L. Slattery,Melissa C. Southey,Zsofia K. Stadler,Christa Stegmaier,Yu Ru Su,Catherine M. Tangen,Stephen N. Thibodeau,Duncan C. Thomas,Sushma S. Thomas,Amanda E. Toland,Antonia Trichopoulou,Cornelia M. Ulrich,David Van Den Berg,Fränzel J.B. Van Duijnhoven,Bethany Van Guelpen,Henk J. van Kranen,Joseph Vijai,Kala Visvanathan,Pavel Vodicka,Pavel Vodicka,Ludmila Vodickova,Ludmila Vodickova,Veronika Vymetalkova,Veronika Vymetalkova,Korbinian Weigl,Korbinian Weigl,Stephanie J. Weinstein,Emily White,Aung Ko Win,Aung Ko Win,C. Roland Wolf,Alicja Wolk,Alicja Wolk,Michael O. Woods,Anna H. Wu,Syed H.E. Zaidi,Brent W. Zanke,Qing Zhang,Wei Zheng,Peter C. Scacheri,John D. Potter,Michael C. Bassik,Anshul Kundaje,Graham Casey,Victor Moreno,Gonçalo R. Abecasis,Deborah A. Nickerson,Stephen B. Gruber,Li Hsu,Li Hsu,Ulrike Peters,Ulrike Peters +224 more
TL;DR: Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.
Journal ArticleDOI
Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults
Mariaelisa Graff,Robert A. Scott,Anne E. Justice,Kristin L. Young,Mary F. Feitosa,Llilda Barata,Thomas W. Winkler,Audrey Y. Chu,Audrey Y. Chu,Anubha Mahajan,David Hadley,Luting Xue,Luting Xue,Tsegaselassie Workalemahu,Nancy L. Heard-Costa,Nancy L. Heard-Costa,Marcel den Hoed,Marcel den Hoed,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Qibin Qi,Julius S. Ngwa,Frida Renström,Frida Renström,Lydia Quaye,John D. Eicher,James E. Hayes,James E. Hayes,Marilyn C. Cornelis,Marilyn C. Cornelis,Marilyn C. Cornelis,Zoltán Kutalik,Zoltán Kutalik,Elise Lim,Jian'an Luan,Jennifer E. Huffman,Jennifer E. Huffman,Weihua Zhang,Weihua Zhang,Wei Zhao,Paula J. Griffin,Toomas Haller,Shafqat Ahmad,Pedro Marques-Vidal,Stephanie A. Bien,Loic Yengo,Alexander Teumer,Albert V. Smith,Meena Kumari,Marie Neergaard Harder,Johanne Marie Justesen,Marcus E. Kleber,Marcus E. Kleber,Mette Hollensted,Kurt Lohman,Natalia V. Rivera,John Whitfield,Jing Hua Zhao,Heather M. Stringham,Leo-Pekka Lyytikäinen,Charlotte Huppertz,Charlotte Huppertz,Gonneke Willemsen,Gonneke Willemsen,Wouter J. Peyrot,Ying Wu,Kati Kristiansson,Kati Kristiansson,Ayse Demirkan,Ayse Demirkan,Myriam Fornage,Maija Hassinen,Lawrence F. Bielak,Gemma Cadby,Toshiko Tanaka,Reedik Mägi,Peter J. van der Most,Anne U. Jackson,Jennifer L. Bragg-Gresham,Veronique Vitart,Jonathan Marten,Pau Navarro,Claire Bellis,Claire Bellis,Dorota Pasko,Åsa Johansson,Soren Snitker,Yu-Ching Cheng,Joel Eriksson,Unhee Lim,Mette Aadahl,Mette Aadahl,Linda S. Adair,Najaf Amin,Beverley Balkau,Juha Auvinen,Juha Auvinen,John Beilby,John Beilby,Richard N. Bergman,Sven Bergmann,Sven Bergmann,Alain G. Bertoni,John Blangero,Amélie Bonnefond,Lori L. Bonnycastle,Judith B. Borja,Soren Brage,Fabio Busonero,Steve Buyske,Harry Campbell,Peter S. Chines,Francis S. Collins,Tanguy Corre,Tanguy Corre,George Davey Smith,Graciela E. Delgado,Nicole Dueker,Marcus Dörr,Tapani Ebeling,Tapani Ebeling,Gudny Eiriksdottir,Tõnu Esko,Jessica D. Faul,Mao Fu,Kristine Færch,Christian Gieger,Sven Gläser,Jian Gong,Penny Gordon-Larsen,Harald Grallert,Tanja B. Grammer,Niels Grarup,Gerard van Grootheest,Kennet Harald,Nicholas D. Hastie,Aki S. Havulinna,Dena G. Hernandez,Lucia A. Hindorff,Lynne J. Hocking,Lynne J. Hocking,Oddgeir L. Holmens,Christina Holzapfel,Jouke-Jan Hottenga,Jie Huang,Tao Huang,Jennie Hui,Jennie Hui,Cornelia Huth,Nina Hutri-Kähönen,Alan James,Alan James,John-Olov Jansson,Min A. Jhun,Markus Juonala,Markus Juonala,Leena Kinnunen,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Ivana Kolcic,Pirjo Komulainen,Johanna Kuusisto,Kirsti Kvaløy,Mika Kähönen,Timo A. Lakka,Lenore J. Launer,Benjamin Lehne,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren,Mattias Lorentzon,Mattias Lorentzon,Robert Luben,Michel Marre,Yuri Milaneschi,Keri L. Monda,Keri L. Monda,Grant W. Montgomery,Marleen H.M. de Moor,Marleen H.M. de Moor,Antonella Mulas,Martina Müller-Nurasyid,Arthur W. Musk,Arthur W. Musk,Reija Männikkö,Satu Männistö,Narisu Narisu,Matthias Nauck,Jennifer A. Nettleton,Ilja M. Nolte,Albertine J. Oldehinkel,Matthias Olden,Ken K. Ong,Sandosh Padmanabhan,Sandosh Padmanabhan,Lavinia Paternoster,Jeremiah Perez,Markus Perola,Markus Perola,Markus Perola,Annette Peters,Ulrike Peters,Patricia A. Peyser,Inga Prokopenko,Hannu Puolijoki,Olli T. Raitakari,Olli T. Raitakari,Tuomo Rankinen,Laura J. Rasmussen-Torvik,Rajesh Rawal,Paul M. Ridker,Paul M. Ridker,Lynda M. Rose,Igor Rudan,Cinzia Sarti,Mark A. Sarzynski,Kai Savonen,William R. Scott,Serena Sanna,Alan R. Shuldiner,Steve Sidney,Günther Silbernagel,Blair H. Smith,Blair H. Smith,Jennifer A. Smith,Harold Snieder,Alena Stančáková,Barbara Sternfeld,Amy J. Swift,Tuija Tammelin,Sian-Tsung Tan,Barbara Thorand,Dorothée Thuillier,Liesbeth Vandenput,Henrik Vestergaard,Henrik Vestergaard,Jana V. van Vliet-Ostaptchouk,Marie-Claude Vohl,Uwe Völker,Gérard Waeber,Mark Walker,Sarah H. Wild,Andrew Wong,Alan F. Wright,M. Carola Zillikens,Niha Zubair,Christopher A. Haiman,Loic LeMarchand,Ulf Gyllensten,Claes Ohlsson,Albert Hofman,Albert Hofman,Fernando Rivadeneira,Fernando Rivadeneira,André G. Uitterlinden,Louis Pérusse,James F. Wilson,Caroline Hayward,Ozren Polasek,Francesco Cucca,Kristian Hveem,Catharina A. Hartman,Anke Tönjes,Stefania Bandinelli,Lyle J. Palmer,Sharon L.R. Kardia,Rainer Rauramaa,Thorkild I. A. Sørensen,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Veikko Salomaa,Brenda W.J.H. Penninx,Eco J. C. de Geus,Eco J. C. de Geus,Dorret I. Boomsma,Terho Lehtimäki,Massimo Mangino,Massimo Mangino,Markku Laakso,Claude Bouchard,Nicholas G. Martin,Diana Kuh,Yongmei Liu,Allan Linneberg,Allan Linneberg,Winfried März,Winfried März,Winfried März,Konstantin Strauch,Mika Kivimäki,Tamara B. Harris,Vilmundur Gudnason,Henry Völzke,Lu Qi,Marjo-Riitta Järvelin,John C. Chambers,John C. Chambers,John C. Chambers,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Philippe Froguel,Philippe Froguel,Charles Kooperberg,Peter Vollenweider,Göran Hallmans,Torben Hansen,Oluf Pedersen,Andres Metspalu,Nicholas J. Wareham,Claudia Langenberg,David R. Weir,David J. Porteous,Eric Boerwinkle,Daniel I. Chasman,Daniel I. Chasman,Daniel I. Chasman,Gonçalo R. Abecasis,Inês Barroso,Inês Barroso,Mark I. McCarthy,Mark I. McCarthy,Timothy M. Frayling,Jeffrey R. O'Connell,Cornelia M. van Duijn,Cornelia M. van Duijn,Michael Boehnke,Iris M. Heid,Karen L. Mohlke,David P. Strachan,Caroline S. Fox,Ching-Ti Liu,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Robert J. Klein,Andrew D. Johnson,Ingrid B. Borecki,Paul W. Franks,Paul W. Franks,Paul W. Franks,Kari E. North,L. Adrienne Cupples,L. Adrienne Cupples,Ruth J. F. Loos,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen +349 more
TL;DR: In additional genome-wide meta-analyses adjusting for PA and interaction with PA, 11 novel adiposity loci are identified, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
Journal ArticleDOI
Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors.
Jihyoun Jeon,Mengmeng Du,Robert E. Schoen,Michael Hoffmeister,Polly A. Newcomb,Sonja I. Berndt,Bette J. Caan,Peter T. Campbell,Andrew T. Chan,Andrew T. Chan,Jenny Chang-Claude,Graham G. Giles,Jian Gong,Tabitha A. Harrison,Jeroen R. Huyghe,Eric J. Jacobs,Li Li,Yi Lin,Loic Le Marchand,John D. Potter,Conghui Qu,Stephanie A. Bien,Niha Zubair,Robert J. MacInnis,Daniel D. Buchanan,Daniel D. Buchanan,John L. Hopper,John L. Hopper,Yin Cao,Reiko Nishihara,Gad Rennert,Martha L. Slattery,Duncan C. Thomas,Michael O. Woods,Ross L. Prentice,Stephen B. Gruber,Yingye Zheng,Hermann Brenner,Richard B. Hayes,Emily White,Ulrike Peters,Li Hsu +41 more
TL;DR: The models determined risk of CRC and starting ages for screening with greater accuracy than the family history only model, which is based on the current screening guideline, might serve as a first step toward developing individualized CRC prevention strategies.
Journal ArticleDOI
Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations
Madeline H. Kowalski,Huijun Qian,Ziyi Hou,Jonathan D. Rosen,Amanda L. Tapia,Yue Shan,Deepti Jain,Maria Argos,Donna K. Arnett,Christy L. Avery,Kathleen C. Barnes,Lewis C. Becker,Stephanie A. Bien,Joshua C. Bis,John Blangero,Eric Boerwinkle,Donald W. Bowden,Steve Buyske,Jianwen Cai,Michael H. Cho,Michael H. Cho,Seung Hoan Choi,Hélène Choquet,L. Adrienne Cupples,Mary Cushman,Michelle Daya,Paul S. de Vries,Patrick T. Ellinor,Patrick T. Ellinor,Nauder Faraday,Myriam Fornage,Stacey Gabriel,Santhi K. Ganesh,Misa Graff,Namrata Gupta,Jiang He,Susan R. Heckbert,Susan R. Heckbert,Bertha Hidalgo,Chani J. Hodonsky,Marguerite R. Irvin,Andrew D. Johnson,Eric Jorgenson,Robert C. Kaplan,Sharon L.R. Kardia,Tanika N. Kelly,Charles Kooperberg,Jessica Lasky-Su,Jessica Lasky-Su,Ruth J. F. Loos,Steven A. Lubitz,Steven A. Lubitz,Rasika A. Mathias,Caitlin P. McHugh,Courtney G. Montgomery,Jee-Young Moon,Alanna C. Morrison,Nicholette D. Palmer,Nathan Pankratz,George Papanicolaou,Juan M. Peralta,Patricia A. Peyser,Stephen S. Rich,Jerome I. Rotter,Edwin K. Silverman,Edwin K. Silverman,Jennifer A. Smith,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Kent D. Taylor,Timothy A. Thornton,Hemant K. Tiwari,Russell P. Tracy,Tao Wang,Scott T. Weiss,Scott T. Weiss,Lu-Chen Weng,Kerri L. Wiggins,James G. Wilson,Lisa R. Yanek,Sebastian Zöllner,Kari E. North,Paul L. Auer,Laura M. Raffield,Alex P. Reiner,Yun Li +86 more
TL;DR: It is demonstrated that using TOPMed sequencing data as the imputation reference panel improves genotypes into admixed African and Hispanic/Latino samples with genome-wide genotyping array data, which subsequently enhanced gene-mapping power for complex traits.