A
Amrita Singh
Researcher at Howard Hughes Medical Institute
Publications - 6
Citations - 385
Amrita Singh is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Stereotypy (non-human) & Paleontology. The author has an hindex of 4, co-authored 5 publications receiving 255 citations. Previous affiliations of Amrita Singh include Johns Hopkins University & Indian Institute of Technology Kanpur.
Papers
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Journal ArticleDOI
Bright and photostable chemigenetic indicators for extended in vivo voltage imaging.
Ahmed S. Abdelfattah,Takashi Kawashima,Amrita Singh,Amrita Singh,Ondrej Novak,Ondrej Novak,Hui Liu,Yichun Shuai,Yi Chieh Huang,Luke Campagnola,Stephanie C. Seeman,Jianing Yu,Jihong Zheng,Jonathan B. Grimm,Ronak Patel,Johannes Friedrich,Brett D. Mensh,Liam Paninski,John J. Macklin,Gabe J. Murphy,Kaspar Podgorski,Bei Jung Lin,Tsai Wen Chen,Glenn C. Turner,Zhe Liu,Minoru Koyama,Karel Svoboda,Misha B. Ahrens,Luke D. Lavis,Eric R. Schreiter +29 more
TL;DR: A GEVI is engineered, called Voltron, that uses bright and photostable synthetic dyes instead of protein-based fluorophores, thereby extending the number of neurons imaged simultaneously in vivo by a factor of 10 and enabling imaging for significantly longer durations relative to existing GEVIs.
Posted ContentDOI
Bright and photostable chemigenetic indicators for extended in vivo voltage imaging
Ahmed S. Abdelfattah,Takashi Kawashima,Amrita Singh,Ondrej Novak,Hui Liu,Yichun Shuai,Yi Chieh Huang,Jonathan B. Grimm,Ronak Patel,Johannes Friedrich,Brett D. Mensh,Liam Paninski,John J. Macklin,Kaspar Podgorski,Bei Jung Lin,Tsai Wen Chen,Glenn C. Turner,Zhe Liu,Minoru Koyama,Karel Svoboda,Misha B. Ahrens,Luke D. Lavis,Eric R. Schreiter +22 more
TL;DR: A novel GEVI is engineered, ‘Voltron’, that utilizes bright and photostable synthetic dyes instead of protein-based fluorophores, extending the combined duration of imaging and number of neurons imaged simultaneously by more than tenfold relative to existing GEVIs.
Journal ArticleDOI
Multiple network properties overcome random connectivity to enable stereotypic sensory responses.
Aarush Mohit Mittal,Diksha Gupta,Diksha Gupta,Amrita Singh,Amrita Singh,Andrew C. Lin,Nitin Gupta +6 more
TL;DR: The authors reveal the network mechanisms that enable stereotypic sensory responses across individuals and reveal the fundamental mechanisms and constraints with which convergence enables stereotypy in sensory responses despite random connectivity.
Journal ArticleDOI
High-fidelity estimates of spikes and subthreshold waveforms from 1-photon voltage imaging in vivo.
Michael E. Xie,Yoav Adam,Linlin Z. Fan,Urs Lucas Böhm,Ian Kinsella,Ding Zhou,Márton Rózsa,Amrita Singh,Karel Svoboda,Liam Paninski,Adam E. Cohen +10 more
TL;DR: In this paper, a spike-guided penalized matrix decomposition-nonnegative matrix factorization (SGPMD-NMF) was proposed to resolve supra-and sub-threshold voltages in vivo.
Journal ArticleDOI
VolPy: Automated and scalable analysis pipelines for voltage imaging datasets.
Changjia Cai,Johannes Friedrich,Amrita Singh,M. Hossein Eybposh,Eftychios A. Pnevmatikakis,Kaspar Podgorski,Andrea Giovannucci +6 more
TL;DR: VolPy as mentioned in this paper is an automated and scalable pipeline to pre-process voltage imaging datasets, which features motion correction, memory mapping, automated segmentation, denoising and spike extraction, all built on a highly parallelizable, modular, and extensible framework optimized for memory and speed.