A
André Groyer
Researcher at French Institute of Health and Medical Research
Publications - 29
Citations - 1483
André Groyer is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Protein kinase B & Gene expression. The author has an hindex of 18, co-authored 29 publications receiving 1418 citations. Previous affiliations of André Groyer include Paris Diderot University & University of Paris.
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Journal ArticleDOI
Identification of Restricted Subsets of Mature microRNA Abnormally Expressed in Inactive Colonic Mucosa of Patients with Inflammatory Bowel Disease
Magali Fasseu,Xavier Treton,Xavier Treton,Cécile Guichard,Cécile Guichard,Eric Pedruzzi,Eric Pedruzzi,Dominique Cazals-Hatem,Dominique Cazals-Hatem,Christophe Richard,Christophe Richard,Thomas Aparicio,Thomas Aparicio,Fanny Daniel,Fanny Daniel,Soulé Jc,Soulé Jc,Richard Moreau,Richard Moreau,Yoram Bouhnik,Yoram Bouhnik,Marc Laburthe,Marc Laburthe,André Groyer,André Groyer,Eric Ogier-Denis,Eric Ogier-Denis +26 more
TL;DR: This study supports miRNAs as crucial players in the onset and/or relapse of inflammation from quiescent mucosal tissues in IBD patients and suggests that some of the miRNA with altered expression in the quiescence mucosa of I BD patients may define miRNA signatures for UC and CD and help develop new diagnostic biomarkers.
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An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis.
TL;DR: It is suggested that the IGF system and IGF-IR signalling may play a role in hepatocarcinogenesis and in deregulated proliferation and apoptosis of HCC cells, and care must be taken when designing combinations of antitumoural molecules for antineoplastic treatment.
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Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro
André Groyer,Ghislaine Schweizer-Groyer,Françoise Cadepond,Marcel Mariller,Etienne-Emile Baulieu +4 more
TL;DR: The results suggest that the lack of affinity for DNA of the 8S form of GR may be attributable in vivo to the interaction of the 4S-GR protein with hsp 90, and that hormone binding might trigger a conformational change which results in the release of active 4s-GR.
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NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon
Nicolas Coant,Sanae Ben Mkaddem,Sanae Ben Mkaddem,Eric Pedruzzi,Eric Pedruzzi,Cécile Guichard,Cécile Guichard,Xavier Treton,Xavier Treton,Robert Ducroc,Robert Ducroc,Jean-Noël Freund,Dominique Cazals-Hatem,Yoram Bouhnik,Yoram Bouhnik,Paul-Louis Woerther,David Skurnik,Alain Grodet,Alain Grodet,Michèle Fay,Michèle Fay,Denis Biard,Thécla Lesuffleur,Christine Deffert,Richard Moreau,Richard Moreau,André Groyer,André Groyer,Karl-Heinz Krause,Fanny Daniel,Fanny Daniel,Eric Ogier-Denis,Eric Ogier-Denis +32 more
TL;DR: It is concluded that NADPH oxidase 1 controls the balance between goblet and absorptive cell types in the colon by coordinately modulating PI3K/AKT/Wnt/β-catenin and Notch1 signaling.
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Altered Endoplasmic Reticulum Stress Affects Translation in Inactive Colon Tissue From Patients With Ulcerative Colitis
Xavier Treton,Xavier Treton,Eric Pedruzzi,Eric Pedruzzi,Dominique Cazals–Hatem,Dominique Cazals–Hatem,Alain Grodet,Alain Grodet,Yves Panis,André Groyer,André Groyer,Richard Moreau,Richard Moreau,Yoram Bouhnik,Yoram Bouhnik,Fanny Daniel,Fanny Daniel,Eric Ogier–Denis,Eric Ogier–Denis +18 more
TL;DR: Colonic mucosa samples from patients with UC have defects in the eIF2α pathway that controls protein translation and the cell stress response, and this pathway might be investigated to identify new therapeutic targets for patients withUC.