N
Nicolas Coant
Researcher at Paris Diderot University
Publications - 10
Citations - 464
Nicolas Coant is an academic researcher from Paris Diderot University. The author has contributed to research in topics: Lipid signaling & Ceramide. The author has an hindex of 7, co-authored 8 publications receiving 414 citations. Previous affiliations of Nicolas Coant include French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon
Nicolas Coant,Sanae Ben Mkaddem,Sanae Ben Mkaddem,Eric Pedruzzi,Eric Pedruzzi,Cécile Guichard,Cécile Guichard,Xavier Treton,Xavier Treton,Robert Ducroc,Robert Ducroc,Jean-Noël Freund,Dominique Cazals-Hatem,Yoram Bouhnik,Yoram Bouhnik,Paul-Louis Woerther,David Skurnik,Alain Grodet,Alain Grodet,Michèle Fay,Michèle Fay,Denis Biard,Thécla Lesuffleur,Christine Deffert,Richard Moreau,Richard Moreau,André Groyer,André Groyer,Karl-Heinz Krause,Fanny Daniel,Fanny Daniel,Eric Ogier-Denis,Eric Ogier-Denis +32 more
TL;DR: It is concluded that NADPH oxidase 1 controls the balance between goblet and absorptive cell types in the colon by coordinately modulating PI3K/AKT/Wnt/β-catenin and Notch1 signaling.
Journal ArticleDOI
Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells
Julien Véret,Nicolas Coant,Evgeny V. Berdyshev,Anastasia Skobeleva,Nicole Therville,D. Bailbé,Irina Gorshkova,Viswanathan Natarajan,Bernard Portha,Hervé Le Stunff +9 more
TL;DR: The results suggest that glucolipotoxicity induces β-cell apoptosis through a dual mechanism involving de novo ceramide biosynthesis and the formation of ceramides with specific N-acyl chain lengths rather than an overall increase in ceramide content.
Journal ArticleDOI
Ex vivo effects of high-density lipoprotein exposure on the lipopolysaccharide-induced inflammatory response in patients with severe cirrhosis.
Arnaud Galbois,Dominique Thabut,Khalid A. Tazi,Khalid A. Tazi,Marika Rudler,Marika Rudler,Morvarid Shir Mohammadi,Morvarid Shir Mohammadi,Dominique Bonnefont-Rousselot,Hind Bennani,Annie Bezeaud,Zéra Tellier,Cécile Guichard,Cécile Guichard,Nicolas Coant,Eric Ogier-Denis,Richard Moreau,Richard Moreau,Didier Lebrec,Didier Lebrec +19 more
TL;DR: High‐density lipoproteins (rHDL) abolishes the LPS‐induced overproduction of proinflammatory cytokines in whole blood from patients with severe cirrhosis, suggesting that administration of rHDL might be a useful strategy for the treatment of Cirrhosis to limit L PS‐induced cytokine overproduction.
Journal ArticleDOI
Hippocampal lipoprotein lipase regulates energy balance in rodents.
Alexandre Picard,Claude Rouch,Claude Rouch,Nadim Kassis,Nadim Kassis,Valentine S. Moullé,Sophie Croizier,Raphael G. P. Denis,Julien Castel,Julien Castel,Nicolas Coant,Katie Ellen Davis,Deborah J. Clegg,Stephen C. Benoit,Vincent Prevot,Sebastien G. Bouret,Sebastien G. Bouret,Serge Luquet,Serge Luquet,Hervé Le Stunff,Céline Cruciani-Guglielmacci,Christophe Magnan +21 more
TL;DR: It is concluded that hippocampal lipid sensing might represent a core mechanism for energy homeostasis regulation through de novo ceramide synthesis and neurogenesis in the hippocampus.
Journal ArticleDOI
Glycogen synthase kinase 3 involvement in the excessive proinflammatory response to LPS in patients with decompensated cirrhosis.
Nicolas Coant,Marika Simon-Rudler,Thierry Gustot,Thierry Gustot,Magali Fasseu,Sonia Gandoura,Kévin Ragot,Waël Abdel-Razek,Dominique Thabut,Philippe Lettéron,Philippe Lettéron,Eric Ogier-Denis,Eric Ogier-Denis,Romy Ouziel,Jacques Devière,Gérard Lizard,Zéra Tellier,Didier Lebrec,Didier Lebrec,Richard Moreau,Richard Moreau +20 more
TL;DR: GSK3 is involved in the early TLR4-mediated pro-inflammatory response in patients with decompensated cirrhosis and normal subjects, and was associated with a defect in AKT-mediated GSK3β phosphorylation resulting in unrestricted 'pro-inflammatory' activity of the enzyme.