S
Sanae Ben Mkaddem
Researcher at Paris Diderot University
Publications - 37
Citations - 1871
Sanae Ben Mkaddem is an academic researcher from Paris Diderot University. The author has contributed to research in topics: Signal transduction & Innate immune system. The author has an hindex of 21, co-authored 35 publications receiving 1469 citations. Previous affiliations of Sanae Ben Mkaddem include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura).
Marieke H. Heineke,Aranka V Ballering,Agnès Jamin,Sanae Ben Mkaddem,Renato C. Monteiro,Marjolein van Egmond +5 more
TL;DR: The putative role of IgA, IgA receptors, neutrophils and other factors such as infections, genetics and the complement system in the pathogenesis of Ig a vasculitis are discussed.
Journal ArticleDOI
NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon
Nicolas Coant,Sanae Ben Mkaddem,Sanae Ben Mkaddem,Eric Pedruzzi,Eric Pedruzzi,Cécile Guichard,Cécile Guichard,Xavier Treton,Xavier Treton,Robert Ducroc,Robert Ducroc,Jean-Noël Freund,Dominique Cazals-Hatem,Yoram Bouhnik,Yoram Bouhnik,Paul-Louis Woerther,David Skurnik,Alain Grodet,Alain Grodet,Michèle Fay,Michèle Fay,Denis Biard,Thécla Lesuffleur,Christine Deffert,Richard Moreau,Richard Moreau,André Groyer,André Groyer,Karl-Heinz Krause,Fanny Daniel,Fanny Daniel,Eric Ogier-Denis,Eric Ogier-Denis +32 more
TL;DR: It is concluded that NADPH oxidase 1 controls the balance between goblet and absorptive cell types in the colon by coordinately modulating PI3K/AKT/Wnt/β-catenin and Notch1 signaling.
Journal ArticleDOI
Understanding Fc Receptor Involvement in Inflammatory Diseases: From Mechanisms to New Therapeutic Tools
TL;DR: The role of FcRs in autoimmune diseases is discussed, and novel approaches to target Fc receptors for resolution of antibody-mediated autoimmunity are focused on.
Book ChapterDOI
IgA, IgA receptors, and their anti-inflammatory properties.
Sanae Ben Mkaddem,Ivy Christou,Elisabetta Rossato,Laureline Berthelot,Agnès Lehuen,Renato C. Monteiro +5 more
TL;DR: Serum monomeric IgA can mediate a potent anti-inflammatory function following the sugar-dependent interaction with SIGNR1 on dendritic cells which induces an immune tolerance via regulatory T cell expansion.
Journal ArticleDOI
IgG1 and IVIg induce inhibitory ITAM signaling through FcγRIII controlling inflammatory responses
Meryem Aloulou,Meryem Aloulou,Sanae Ben Mkaddem,Sanae Ben Mkaddem,Martine Biarnes-Pelicot,Martine Biarnes-Pelicot,Tarek Boussetta,Tarek Boussetta,Hervé Souchet,Hervé Souchet,Elisabetta Rossato,Elisabetta Rossato,Marc Benhamou,Marc Benhamou,Bruno Crestani,Bruno Crestani,Zhou Zhu,Ulrich Blank,Ulrich Blank,Pierre Launay,Pierre Launay,Renato C. Monteiro,Renato C. Monteiro +22 more
TL;DR: Results demonstrate that circulating immunoglobulins (Ig)Gs are not functionally inert but act through continuous interaction with FcγRIII-inducing ITAMi signaling to maintain immune homeostasis and support a new mechanism of action for IVIg.