C
Christine Deffert
Researcher at Geneva College
Publications - 28
Citations - 1881
Christine Deffert is an academic researcher from Geneva College. The author has contributed to research in topics: NADPH oxidase & Chronic granulomatous disease. The author has an hindex of 19, co-authored 27 publications receiving 1683 citations. Previous affiliations of Christine Deffert include University of Geneva.
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Journal ArticleDOI
Decreased blood pressure in NOX1-deficient mice.
Gaëtan Gavazzi,Botond Banfi,Christine Deffert,Laurence Fiette,Michela G. Schäppi,François Herrmann,Karl-Heinz Krause +6 more
TL;DR: A role for NOX1 in blood pressure regulation and vascular angiotensin II response is established and a marked reduction in aortic media hypertrophy is shown.
Journal ArticleDOI
A Key Role for NOX4 in Epithelial Cell Death During Development of Lung Fibrosis
Stephanie Carnesecchi,Christine Deffert,Yves Donati,Olivier Basset,Boris Hinz,Olivier Preynat-Seauve,Cécile Guichard,Jack L. Arbiser,Botond Banfi,Jean-Claude Pache,Constance Barazzone-Argiroffo,Karl-Heinz Krause +11 more
TL;DR: It is demonstrated that in lungs of patients with idiopathic lung fibrosis, there is strong expression of NOX4 in hyperplastic alveolar type II cells, and ROS generation by Nox4 is a key player in epithelial cell death leading to pulmonary fibrosis.
Journal ArticleDOI
NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon
Nicolas Coant,Sanae Ben Mkaddem,Sanae Ben Mkaddem,Eric Pedruzzi,Eric Pedruzzi,Cécile Guichard,Cécile Guichard,Xavier Treton,Xavier Treton,Robert Ducroc,Robert Ducroc,Jean-Noël Freund,Dominique Cazals-Hatem,Yoram Bouhnik,Yoram Bouhnik,Paul-Louis Woerther,David Skurnik,Alain Grodet,Alain Grodet,Michèle Fay,Michèle Fay,Denis Biard,Thécla Lesuffleur,Christine Deffert,Richard Moreau,Richard Moreau,André Groyer,André Groyer,Karl-Heinz Krause,Fanny Daniel,Fanny Daniel,Eric Ogier-Denis,Eric Ogier-Denis +32 more
TL;DR: It is concluded that NADPH oxidase 1 controls the balance between goblet and absorptive cell types in the colon by coordinately modulating PI3K/AKT/Wnt/β-catenin and Notch1 signaling.
Journal ArticleDOI
Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism.
Sarah Garrido-Urbani,Stephane Jemelin,Christine Deffert,Stephanie Carnesecchi,Olivier Basset,Cedric Szyndralewiez,Freddy Heitz,Patrick Page,Xavier Montet,Liliane Michalik,Jack L. Arbiser,Curzio Rüegg,Karl-Heinz Krause,Beat A. Imhof +13 more
TL;DR: Vascular NOX1 is a critical mediator of angiogenesis and an attractive target for anti-angiogenic therapies.
Journal ArticleDOI
NADPH Oxidase-1 Plays a Crucial Role in Hyperoxia-induced Acute Lung Injury in Mice
Stephanie Carnesecchi,Christine Deffert,Alessandra Pagano,Sarah Garrido-Urbani,Isabelle Métrailler-Ruchonnet,Michela G. Schäppi,Yves Donati,Michael A. Matthay,Karl-Heinz Krause,Constance Barazzone Argiroffo +9 more
TL;DR: NoX1 is an important contributor to ROS production and cell death of the alveolocapillary barrier during hyperoxia and is an upstream actor in oxidative stress-induced acute lung injury involving JNK and ERK pathways in mice.