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Andrea Flex
Researcher at Catholic University of the Sacred Heart
Publications - 55
Citations - 3414
Andrea Flex is an academic researcher from Catholic University of the Sacred Heart. The author has contributed to research in topics: Diabetes mellitus & Internal medicine. The author has an hindex of 18, co-authored 44 publications receiving 3121 citations. Previous affiliations of Andrea Flex include Sapienza University of Rome.
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Journal ArticleDOI
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.
Thorgeir E. Thorgeirsson,Frank Geller,Patrick Sulem,Thorunn Rafnar,Anna Wiste,Anna Wiste,Kristinn P. Magnusson,Andrei Manolescu,Gudmar Thorleifsson,Hreinn Stefansson,Andres Ingason,Simon N. Stacey,Jon Thor Bergthorsson,Steinunn Thorlacius,Julius Gudmundsson,Thorlakur Jonsson,Margret Jakobsdottir,Jona Saemundsdottir,Olof Birna Olafsdottir,Larus J. Gudmundsson,Gyda Bjornsdottir,Kristleifur Kristjansson,Halla Skuladottir,Helgi J Isaksson,Tomas Gudbjartsson,Gregory T. Jones,Thomas Mueller,Anders Gottsäter,Andrea Flex,Katja K.H. Aben,Femmie de Vegt,Peter F.A. Mulders,Dolores Isla,Maria Vidal,Laura Asín,Berta Saez,L. Murillo,Thorsteinn Blondal,Halldor Kolbeinsson,Jón G. Stefánsson,Ingunn Hansdottir,Valgerdur Runarsdottir,Roberto Pola,Bengt Lindblad,Andre M. van Rij,Benjamin Dieplinger,Meinhard Haltmayer,Jose I. Mayordomo,Lambertus A. Kiemeney,Stefan E Matthiasson,Hogni Oskarsson,Thorarinn Tyrfingsson,Daniel F. Gudbjartsson,Jeffrey R. Gulcher,Steinn Jonsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson,Kari Stefansson +59 more
TL;DR: A common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking-related diseases in populations of European descent is identified.
Journal ArticleDOI
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
Anna Helgadottir,Gudmar Thorleifsson,Kristinn P. Magnusson,Solveig Gretarsdottir,Valgerdur Steinthorsdottir,Andrei Manolescu,Gregory T. Jones,Gabriel J.E. Rinkel,Jan D. Blankensteijn,Antti Ronkainen,Juha Jääskeläinen,Yoshiki Kyo,Guy M. Lenk,Natzi Sakalihasan,Konstantinos Kostulas,Anders Gottsäter,Andrea Flex,Hreinn Stefansson,Torben Hansen,Gitte Andersen,Shantel Weinsheimer,Knut Borch-Johnsen,Knut Borch-Johnsen,Torben Jørgensen,Svati H. Shah,Arshed A. Quyyumi,Christopher B. Granger,Muredach P. Reilly,Harland Austin,Allan I. Levey,Viola Vaccarino,Ebba Palsdottir,G. Bragi Walters,Thorbjorg Jonsdottir,Steinunn Snorradottir,Dana Magnusdottir,Gudmundur H. Gudmundsson,Robert E. Ferrell,Sigurlaug Sveinbjörnsdóttir,Juha Hernesniemi,Juha Hernesniemi,Mika Niemelä,Raymond Limet,Karl Andersen,Gunnar Sigurdsson,Rafn Benediktsson,Eric L.G. Verhoeven,Joep A.W. Teijink,Diederick E. Grobbee,Daniel J. Rader,David A. Collier,Oluf Pedersen,Roberto Pola,Jan Hillert,Bengt Lindblad,Einar M. Valdimarsson,Hulda B Magnadottir,Cisca Wijmenga,Gerard Tromp,Annette F. Baas,Ynte M. Ruigrok,Andre M. van Rij,Helena Kuivaniemi,Janet T. Powell,Stefan E Matthiasson,Jeffrey R. Gulcher,Gudmundur Thorgeirsson,Augustine Kong,Unnur Thorsteinsdottir,Kari Stefansson +69 more
TL;DR: It is reported that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA) and intracranial aneurYSm, but not with T2D, and the role of this sequence variant is not confined to atherosclerotic diseases.
Journal ArticleDOI
Proinflammatory Genetic Profiles in Subjects With History of Ischemic Stroke
Andrea Flex,Eleonora Gaetani,Pierangelo Papaleo,Giuseppe Straface,Anna S. Proia,Giovanni Pecorini,Paolo Tondi,Paolo Pola,Roberto Pola +8 more
TL;DR: Proinflammatory genetic profiles are significantly more common in subjects with stroke history and Synergistic effects between proinflammatory genotypes might be potential markers for cerebrovascular diseases.
Journal ArticleDOI
Synergistic Effect of −174 G/C Polymorphism of the Interleukin-6 Gene Promoter and 469 E/K Polymorphism of the Intercellular Adhesion Molecule-1 Gene in Italian Patients With History of Ischemic Stroke
TL;DR: There is a synergistic effect of IL-6 G/C and ICAM-1 E/K gene polymorphisms in patients with stroke history that may contribute in determining the risk profile for cardiovascular diseases and may merit further investigation as potential therapeutic targets.
Journal ArticleDOI
The −174 G/C Polymorphism of the Interleukin-6 Gene Promoter is Associated with Peripheral Artery Occlusive Disease
Andrea Flex,Eleonora Gaetani,Roberto Pola,Angelo Santoliquido,Francesco Aloi,Pierangelo Papaleo,A. Dal Lago,Enrico Pola,Michele Serricchio,Paolo Tondi,Paolo Pola +10 more
TL;DR: This study indicates a strong association between IL-6 gene polymorphism and PAOD and support the hypothesis that IL- 6 and IL-7 gene polymorphisms are important in the pathophysiology and evolution of ischaemic diseases of the lower limbs.