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Konstantinos Kostulas
Researcher at Karolinska University Hospital
Publications - 27
Citations - 3778
Konstantinos Kostulas is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Stroke & Migraine with aura. The author has an hindex of 18, co-authored 27 publications receiving 3531 citations. Previous affiliations of Konstantinos Kostulas include Karolinska Institutet.
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Journal ArticleDOI
Variants conferring risk of atrial fibrillation on chromosome 4q25
Daniel F. Gudbjartsson,David O. Arnar,Anna Helgadottir,Solveig Gretarsdottir,Hilma Holm,Asgeir Sigurdsson,Adalbjorg Jonasdottir,Adam Baker,Gudmar Thorleifsson,Kristleifur Kristjansson,Arnar Palsson,Thorarinn Blondal,Patrick Sulem,Valgerdur M Backman,Gudmundur A. Hardarson,Ebba Palsdottir,Agnar Helgason,Runa Sigurjonsdottir,Jon Th. Sverrisson,Konstantinos Kostulas,Maggie C.Y. Ng,Larry Baum,Wing-Yee So,Ka Sing Wong,Juliana C.N. Chan,Karen L. Furie,Steven M. Greenberg,Michelle Sale,Peter J. Kelly,Calum A. MacRae,Eric E. Smith,Jonathan Rosand,Jan Hillert,Ronald C.W. Ma,Patrick T. Ellinor,Gudmundur Thorgeirsson,Jeffrey R. Gulcher,Augustine Kong,Unnur Thorsteinsdottir,Kari Stefansson +39 more
TL;DR: A genome-wide association scan is performed, followed by replication studies in three populations of European descent and a Chinese population from Hong Kong and a strong association is found between two sequence variants on chromosome 4q25 and AF.
Journal ArticleDOI
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
Anna Helgadottir,Gudmar Thorleifsson,Kristinn P. Magnusson,Solveig Gretarsdottir,Valgerdur Steinthorsdottir,Andrei Manolescu,Gregory T. Jones,Gabriel J.E. Rinkel,Jan D. Blankensteijn,Antti Ronkainen,Juha Jääskeläinen,Yoshiki Kyo,Guy M. Lenk,Natzi Sakalihasan,Konstantinos Kostulas,Anders Gottsäter,Andrea Flex,Hreinn Stefansson,Torben Hansen,Gitte Andersen,Shantel Weinsheimer,Knut Borch-Johnsen,Knut Borch-Johnsen,Torben Jørgensen,Svati H. Shah,Arshed A. Quyyumi,Christopher B. Granger,Muredach P. Reilly,Harland Austin,Allan I. Levey,Viola Vaccarino,Ebba Palsdottir,G. Bragi Walters,Thorbjorg Jonsdottir,Steinunn Snorradottir,Dana Magnusdottir,Gudmundur H. Gudmundsson,Robert E. Ferrell,Sigurlaug Sveinbjörnsdóttir,Juha Hernesniemi,Juha Hernesniemi,Mika Niemelä,Raymond Limet,Karl Andersen,Gunnar Sigurdsson,Rafn Benediktsson,Eric L.G. Verhoeven,Joep A.W. Teijink,Diederick E. Grobbee,Daniel J. Rader,David A. Collier,Oluf Pedersen,Roberto Pola,Jan Hillert,Bengt Lindblad,Einar M. Valdimarsson,Hulda B Magnadottir,Cisca Wijmenga,Gerard Tromp,Annette F. Baas,Ynte M. Ruigrok,Andre M. van Rij,Helena Kuivaniemi,Janet T. Powell,Stefan E Matthiasson,Jeffrey R. Gulcher,Gudmundur Thorgeirsson,Augustine Kong,Unnur Thorsteinsdottir,Kari Stefansson +69 more
TL;DR: It is reported that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA) and intracranial aneurYSm, but not with T2D, and the role of this sequence variant is not confined to atherosclerotic diseases.
Journal ArticleDOI
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
Daniel F. Gudbjartsson,Hilma Holm,Hilma Holm,Solveig Gretarsdottir,Gudmar Thorleifsson,G. Bragi Walters,Gudmundur Thorgeirsson,Jeffrey R. Gulcher,Ellisiv B. Mathiesen,Ellisiv B. Mathiesen,Inger Njølstad,Audhild Nyrnes,Audhild Nyrnes,Tom Wilsgaard,Erin Mathiesen Hald,Kristian Hveem,Camilla Stoltenberg,Gayle Kucera,Tanya Stubblefield,Shannon Carter,Dan M. Roden,Maggie C.Y. Ng,Larry Baum,Wing-Yee So,Ka Sing Wong,Juliana C.N. Chan,Christian Gieger,H-Erich Wichmann,Andreas Gschwendtner,Martin Dichgans,Gregor Kuhlenbäumer,Klaus Berger,E. Bernd Ringelstein,Steve Bevan,Hugh S. Markus,Konstantinos Kostulas,Jan Hillert,Sigurlaug Sveinbjörnsdóttir,Einar M. Valdimarsson,Maja-Lisa Løchen,Maja-Lisa Løchen,Ronald C.W. Ma,Dawood Darbar,Augustine Kong,David O. Arnar,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +48 more
TL;DR: A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF is identified, and this variant also associated with ischemic stroke and cardioembolic stroke in a combined analysis of five stroke samples.
Journal ArticleDOI
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
Matthew Traylor,Martin Farrall,Elizabeth G. Holliday,Cathie Sudlow,Jemma C. Hopewell,Yu-Ching Cheng,Myriam Fornage,M. Arfan Ikram,Rainer Malik,Steve Bevan,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Mike A. Nalls,W. T. Longstreth,Kerri L. Wiggins,Sunaina Yadav,Eugenio Parati,Anita L. DeStefano,Bradford B. Worrall,Steven J. Kittner,Muhammad Saleem Khan,Alexander P. Reiner,Anna Helgadottir,Anna Helgadottir,Anna Helgadottir,Sefanja Achterberg,Israel Fernandez-Cadenas,Sherine Abboud,Reinhold Schmidt,Matthew Walters,Wei-Min Chen,Wei-Min Chen,E. Bernd Ringelstein,Martin O'Donnell,Weang Kee Ho,Joanna Pera,Robin Lemmens,Bo Norrving,Peter Higgins,Marianne Benn,Michèle M. Sale,Gregor Kuhlenbäumer,Alex S. F. Doney,Astrid M. Vicente,Hossein Delavaran,Ale Algra,Gail Davies,Sofia A. Oliveira,Colin N. A. Palmer,Ian C. Deary,Helena Schmidt,Massimo Pandolfo,Joan Montaner,Cara L. Carty,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Konstantinos Kostulas,José M. Ferro,Natalie R. van Zuydam,Einar M. Valdimarsson,Børge G. Nordestgaard,Arne Lindgren,Vincent Thijs,Agnieszka Slowik,Danish Saleheen,Danish Saleheen,Guillaume Paré,Klaus Berger,Gudmar Thorleifsson,Albert Hofman,Thomas H. Mosley,Braxton D. Mitchell,Karen L. Furie,Robert Clarke,Christopher R Levi,Sudha Seshadri,Andreas Gschwendtner,Giorgio B. Boncoraglio,Pankaj Sharma,Joshua C. Bis,Solveig Gretarsdottir,Bruce M. Psaty,Peter M. Rothwell,Jonathan Rosand,Jonathan Rosand,Jonathan Rosand,James F. Meschia,Kari Stefansson,Kari Stefansson,Martin Dichgans,Hugh S. Markus +91 more
TL;DR: The results show that, although genetic variants can be detected in patients with ischaemic stroke when compared with controls, all associations validated are specific to a stroke subtype, and this finding has two implications.
Journal ArticleDOI
ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma.
Daniel F. Gudbjartsson,Patrick Sulem,Simon N. Stacey,Alisa M. Goldstein,Thorunn Rafnar,Bardur Sigurgeirsson,Kristrun R. Benediktsdottir,Kristin Thorisdottir,Rafn Ragnarsson,Steinunn G Sveinsdottir,Veronica Magnusson,Annika Lindblom,Konstantinos Kostulas,Rafael Botella-Estrada,Virtudes Soriano,Pablo Juberías,Matilde Grasa,Berta Saez,Raquel Andrés,Dominique Scherer,Peter Rudnai,Eugene Gurzau,Kvetoslava Koppova,Lambertus A. Kiemeney,Margret Jakobsdottir,Stacy Steinberg,Agnar Helgason,Solveig Gretarsdottir,Margaret A. Tucker,Jose I. Mayordomo,Eduardo Nagore,Rajesh Kumar,Johan Hansson,Jón Ólafsson,Jeffrey R. Gulcher,Augustine Kong,Unnur Thorsteinsdottir,Kari Stefansson +37 more
TL;DR: The association of all three variants is robust with respect to adjustment for the effect of pigmentation, and the impact of these variants on risk of cutaneous melanoma and basal cell carcinoma in European populations is assessed.