Andrew Roth

TL;DR: A detailed catalog of zebrafish behaviors that covers both larval and adult models is developed, representing a beginning of creating a more comprehensive ethogram ofZebrafish behavior, which will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebra fish neurobehavioral paradigms in their research.

TL;DR: This work evaluates established and novel approaches to uncover the molecular substrates, genetic pathways and neural circuits of anxiety using adult zebrafish, and provides a conceptual framework for the wider application of zebra fish and other aquatic models in anxiety research.

TL;DR: This study examined the effect of group-size in the shoaling paradigm, and evaluated the ability of novel video-tracking tools to accurately track an entire shoal, compared to traditional manual analysis of shoaling phenotypes, demonstrating the capacity of video- tracking technology to assess zebrafish shoaling in a high-throughput and reliable manner.

TL;DR: The sensitivity of zebrafish to behavioral and physiological effects of sub-anesthetic doses of ketamine is demonstrated, further supporting the utility of this species as a model for neuropharmacological research, including testing ketamine and related drugs.

TL;DR: The results support the complex pharmacological profile of ibogaine and its high sensitivity in zebrafish models, dose-dependently affecting multiple behavioral domains, and strongly supports the developing utility of aquatic models in hallucinogenic drug research.