Michael Gebhardt

TL;DR: A detailed catalog of zebrafish behaviors that covers both larval and adult models is developed, representing a beginning of creating a more comprehensive ethogram ofZebrafish behavior, which will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebra fish neurobehavioral paradigms in their research.

TL;DR: The results show that zebrafish are highly sensitive to drugs bi-directionally modulating brain monoamines, generally paralleling rodent and clinical findings, and emphasizes the potential of zebra fish tests to model complex brain disorders associated with monoamine dysregulation.

TL;DR: Overall, zebrafish exposed to serotonergic agents and their combinations exhibit a characteristic top dwelling (surfacing behavior) and hypolocomotion which may represent potential markers of SS-like states inZebrafish, suggesting the developing utility of zebra fish (and other aquatic models) for studying SS.

TL;DR: The mounting evidence to support emotionality in zebrafish and other fishes is outlined, important to justify the validity of zebra fish ‘affective’ paradigms and their utility for basic/translational research of normal and pathological behaviors.

TL;DR: Overall, the results show KYNA has an anxiolytic-like pharmacological effect in zebrafish, and therefore strongly support the utility of zebra fish models in neurotropic drug screening, including drugs acting at central glutamatergic system.