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Anita Ayer
Researcher at Victor Chang Cardiac Research Institute
Publications - 25
Citations - 896
Anita Ayer is an academic researcher from Victor Chang Cardiac Research Institute. The author has contributed to research in topics: Oxidative stress & Heme. The author has an hindex of 13, co-authored 23 publications receiving 670 citations. Previous affiliations of Anita Ayer include University of New South Wales & University of Sydney.
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Journal ArticleDOI
Heme Oxygenases in Cardiovascular Health and Disease.
TL;DR: The roles of heme oxygenases in vascular health and the regulation of processes central to vascular diseases are outlined, followed by an evaluation of the role(s) of Hmx1 and Hmox2 in various diseases such as atherosclerosis, intimal hyperplasia, myocardial infarction, and angiogenesis.
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Cellular redox homeostasis, reactive oxygen species and replicative ageing in Saccharomyces cerevisiae
TL;DR: This review discusses aspects of ROS in relation to replicative ageing in the model organism Saccharomyces cerevisiae, with reference to ROS generated in cells; cellular responses to oxidative stress; and how cells maintain redox homeostasis in different cellular compartments.
Journal ArticleDOI
Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation
Christopher P. Stanley,Ghassan J. Maghzal,Ghassan J. Maghzal,Anita Ayer,Anita Ayer,Jihan Talib,Jihan Talib,Andrew M. Giltrap,Sudhir Shengule,Kathryn Wolhuter,Yutang Wang,Yutang Wang,Preet S. Chadha,Cacang Suarna,Oleksandra Prysyazhna,Oleksandra Prysyazhna,Jenna Scotcher,Jenna Scotcher,Louise L. Dunn,Louise L. Dunn,Fernanda M. Prado,Nghi H. Nguyen,Jephthah O. Odiba,Jonathan B. Baell,Jonathan B. Baell,Johannes-Peter Stasch,Yorihiro Yamamoto,Paolo Di Mascio,Philip Eaton,Philip Eaton,Richard J. Payne,Roland Stocker,Roland Stocker +32 more
TL;DR: Singlet molecular oxygen, produced by indoleamine 2,3-dioxygenase 1 activity, gives rise to a signalling molecule that regulates arterial relaxation under inflammatory conditions, demonstrating a pathophysiological role for 1O2 in mammals through formation of an amino acid-derived hydroperoxide that regulates vascular tone and blood pressure underinflammatory conditions.
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Saccharomyces cerevisiae genes involved in survival of heat shock.
Stefanie Jarolim,Anita Ayer,Bethany Pillay,Allison C. Gee,Alex A. Phrakaysone,Gabriel G. Perrone,Michael Breitenbach,Ian W. Dawes +7 more
TL;DR: More than a thousand genes were identified that led to altered sensitivity to heat shock, with little overlap between them and those previously identified to affect thermotolerance, and Mutations affecting mitochondrial genome maintenance were highly represented in sensitive mutants.
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Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling.
Miles J. De Blasio,Karina N N Huynh,Chengxue Qin,Sarah Rosli,Helen Kiriazis,Anita Ayer,Nelly Cemerlang,Roland Stocker,Xiao-Jun Du,Julie R. McMullen,Rebecca H. Ritchie,Rebecca H. Ritchie +11 more
TL;DR: Chronic CoQ(10) supplementation attenuates aspects of diabetic cardiomyopathy, even in a setting of reduced cardiac PI3K protective signaling, and may be an attractive adjunct therapy for diabetic heart failure.