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Anita Ayer
Researcher at Victor Chang Cardiac Research Institute
Publications - 25
Citations - 896
Anita Ayer is an academic researcher from Victor Chang Cardiac Research Institute. The author has contributed to research in topics: Oxidative stress & Heme. The author has an hindex of 13, co-authored 23 publications receiving 670 citations. Previous affiliations of Anita Ayer include University of New South Wales & University of Sydney.
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Journal ArticleDOI
Transition to 37°C reveals importance of NADPH in mitigating oxidative stress in stored RBCs.
Aline Roch,Nicholas J. Magon,Jessica Maire,Cacang Suarna,Anita Ayer,Sophie Claire Waldvogel,Beat A. Imhof,Mark J. Koury,Roland Stocker,Marc Schapira +9 more
TL;DR: Assessment of red blood cell oxidative status after restoration of body temperature provides a sensitive tool to detect storage-related alterations, and has the potential to improve the quality of stored RBCs for transfusion.
Journal ArticleDOI
COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10.
Michelle C. Bradley,Krista Yang,Lucía Fernández-del-Río,Jennifer Ngo,Anita Ayer,Anita Ayer,Hui S. Tsui,Noelle Alexa Novales,Roland Stocker,Roland Stocker,Orian S. Shirihai,Mario H. Barros,Catherine F. Clarke +12 more
TL;DR: Plate growth and Seahorse assays and LC-MS/MS analysis show that COQ11 deletion rescues respiratory deficiency, sensitivity to lipid peroxidation, and decreased Q6 biosynthesis of the coq10Δ mutant, and immunoblotting suggests that yeast coq11Δ mutants accumulate increased amounts of certain Coq polypeptides and display a stabilized CoQ synthome.
Journal ArticleDOI
The role of mitochondrial reactive oxygen species in insulin resistance.
TL;DR: A review of the evidence linking mitochondrial reactive oxygen species generated within mitochondria with insulin resistance in adipose tissue and skeletal muscle, two major insulin sensitive tissues, is presented in this paper.
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Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q.
Anita Ayer,Anita Ayer,Daniel J. Fazakerley,Daniel J. Fazakerley,Cacang Suarna,Cacang Suarna,Ghassan J. Maghzal,Diba Sheipouri,Kevin J. Lee,Michelle C. Bradley,Lucía Fernández-del-Río,Sergey Tumanov,Sergey Tumanov,Stephanie M Y Kong,Stephanie M Y Kong,Jelske N. van der Veen,Andrian Yang,Andrian Yang,Joshua W. K. Ho,Steven Clarke,David E. James,Ian W. Dawes,Dennis E. Vance,Catherine F. Clarke,René L. Jacobs,Roland Stocker +25 more
TL;DR: In this paper, a quantitative high-throughput method was developed to determine CoQ concentrations in yeast cells, which revealed a previously unrecognized relationship between two spatially distinct lipid pathways with potential implications for the treatment of CoQ deficiencies, mitochondrial oxidative stress/dysfunction and associated diseases.
Journal ArticleDOI
Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation.
Raphael F Queiroz,Raphael F Queiroz,Christopher P. Stanley,Christopher P. Stanley,Kathryn Wolhuter,Stephanie M Y Kong,Ragul Rajivan,Naomi McKinnon,Giang T H Nguyen,Antonella Roveri,Sebastian Guttzeit,Philip Eaton,William A. Donald,Fulvio Ursini,Christine C. Winterbourn,Anita Ayer,Anita Ayer,Anita Ayer,Roland Stocker +18 more
TL;DR: The authors showed that arterial glutathione peroxidases and peroxiredoxins that rapidly eliminate H2O2, have little impact on relaxation of IDO1-expressing arteries.