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Anna Radziszewska
Researcher at University College London
Publications - 29
Citations - 2051
Anna Radziszewska is an academic researcher from University College London. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 8, co-authored 25 publications receiving 950 citations. Previous affiliations of Anna Radziszewska include University College Hospital & Great Ormond Street Hospital.
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Journal ArticleDOI
Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission.
Hannah Peckham,Nina M. de Gruijter,Charles Raine,Anna Radziszewska,Coziana Ciurtin,Lucy R. Wedderburn,Lucy R. Wedderburn,Lucy R. Wedderburn,Elizabeth C. Rosser,Kate Webb,Kate Webb,Claire T Deakin,Claire T Deakin,Claire T Deakin +13 more
TL;DR: A meta-analysis of 3,111,714 reported global cases shows that, whilst there is no difference in the proportion of males and females with confirmed COVID-19, male patients have almost three times the odds of requiring intensive treatment unit (ITU) admission and higher odds of death compared to females.
Journal ArticleDOI
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Kevin W. Ng,Nikhil Faulkner,Georgina H. Cornish,Annachiara Rosa,Ruth Harvey,Saira Hussain,Rachel Ulferts,Christopher Earl,A.G. Wrobel,D.J. Benton,Chloe Roustan,William Bolland,Rachael Thompson,Ana Agua-Doce,Philip Hobson,Judith Heaney,Hannah Rickman,Stavroula Paraskevopoulou,Catherine F Houlihan,Kirsty Thomson,Emilie Sanchez,Gee Yen Shin,Moira J. Spyer,Dhira Joshi,Nicola O’Reilly,Philip A. Walker,Svend Kjaer,Andrew Riddell,Catherine Moore,Bethany R. Jebson,Meredyth G. Ll Wilkinson,Lucy R. Marshall,Elizabeth C. Rosser,Anna Radziszewska,Hannah Peckham,Coziana Ciurtin,Lucy R. Wedderburn,Rupert Beale,Charles Swanton,Sonia Gandhi,Brigitta Stockinger,John W. McCauley,Steve Gamblin,Laura E. McCoy,Peter Cherepanov,Eleni Nastouli,George Kassiotis,George Kassiotis +47 more
TL;DR: Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, preexisting humoral immunity was detected and antibodies targeting the S2 subunit were particularly prevalent in children and adolescents.
Journal ArticleDOI
Sex and Pubertal Differences in the Type 1 Interferon Pathway Associate With Both X Chromosome Number and Serum Sex Hormone Concentration.
Kate Webb,Hannah Peckham,Anna Radziszewska,Madhvi Menon,Paola Oliveri,Fraser Simpson,Claire T Deakin,Sophie Lee,Coziana Ciurtin,Gary Butler,Lucy R. Wedderburn,Yiannis Ioannou +11 more
TL;DR: It is reported that plasmacytoid dendritic cells from healthy females produced more type 1 IFN after toll like receptor (TLR) 7 signaling than males, even before puberty, but that puberty itself associated with increased production of type 1IFN.
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CD19+CD24hiCD38hi B Cells Are Expanded in Juvenile Dermatomyositis and Exhibit a Pro-Inflammatory Phenotype After Activation Through Toll-Like Receptor 7 and Interferon-α.
Christopher Piper,Meredyth G. Ll Wilkinson,Meredyth G. Ll Wilkinson,Claire T Deakin,Claire T Deakin,Claire T Deakin,Georg W. Otto,Georg W. Otto,Stefanie Dowle,Stefanie Dowle,Chantal L. Duurland,Stuart Adams,Emiliano Marasco,Elizabeth C. Rosser,Anna Radziszewska,Anna Radziszewska,Rita Carsetti,Yiannis Ioannou,Yiannis Ioannou,Philip L. Beales,Philip L. Beales,Daniel Kelberman,Daniel Kelberman,David A. Isenberg,David A. Isenberg,Claudia Mauri,Kiran Nistala,Lucy R. Wedderburn,Lucy R. Wedderburn,Lucy R. Wedderburn +29 more
TL;DR: Investigating mechanisms driving B cell lymphocytosis and defining pathological features of B cells in JDM patients found that immature transitional B cells were significantly expanded in active JDM, actively dividing, and correlated positively with disease activity.
Journal ArticleDOI
Disease-associated and patient-specific immune cell signatures in juvenile-onset systemic lupus erythematosus: patient stratification using a machine-learning approach.
George Robinson,Junjie Peng,Pierre Dönnes,Leda Coelewij,Meena Naja,Anna Radziszewska,Chris Wincup,Hannah Peckham,David A. Isenberg,Yiannis Ioannou,Yiannis Ioannou,Ines Pineda-Torra,Coziana Ciurtin,Elizabeth C. Jury +13 more
TL;DR: Patients with juvenile-onset systemic lupus erythematosus and elevated CD8 effector memory T-cell frequencies had more persistently active disease over time, and this was associated with increased treatment with mycophenolate mofetil and an increased prevalence of l upus nephritis.