G
Georgina H. Cornish
Researcher at Francis Crick Institute
Publications - 33
Citations - 1889
Georgina H. Cornish is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 13, co-authored 32 publications receiving 1458 citations. Previous affiliations of Georgina H. Cornish include Imperial College London & King's College London.
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Journal ArticleDOI
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Kevin W. Ng,Nikhil Faulkner,Georgina H. Cornish,Annachiara Rosa,Ruth Harvey,Saira Hussain,Rachel Ulferts,Christopher Earl,A.G. Wrobel,D.J. Benton,Chloe Roustan,William Bolland,Rachael Thompson,Ana Agua-Doce,Philip Hobson,Judith Heaney,Hannah Rickman,Stavroula Paraskevopoulou,Catherine F Houlihan,Kirsty Thomson,Emilie Sanchez,Gee Yen Shin,Moira J. Spyer,Dhira Joshi,Nicola O’Reilly,Philip A. Walker,Svend Kjaer,Andrew Riddell,Catherine Moore,Bethany R. Jebson,Meredyth G. Ll Wilkinson,Lucy R. Marshall,Elizabeth C. Rosser,Anna Radziszewska,Hannah Peckham,Coziana Ciurtin,Lucy R. Wedderburn,Rupert Beale,Charles Swanton,Sonia Gandhi,Brigitta Stockinger,John W. McCauley,Steve Gamblin,Laura E. McCoy,Peter Cherepanov,Eleni Nastouli,George Kassiotis,George Kassiotis +47 more
TL;DR: Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, preexisting humoral immunity was detected and antibodies targeting the S2 subunit were particularly prevalent in children and adolescents.
Journal ArticleDOI
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking.
Linda V. Sinclair,David K. Finlay,Carmen Feijoo,Georgina H. Cornish,Alexander Gray,Ann Ager,Klaus Okkenhaug,Thijs J. Hagenbeek,Hergen Spits,Hergen Spits,Doreen A. Cantrell +10 more
TL;DR: PI(3)K-mTOR nutrient-sensing pathways also determined expression of the chemokine receptor CCR7 and regulated lymphocyte trafficking in vivo, showing that lymphocytes use PI( 3)K and mTOR to match metabolism and trafficking.
Journal ArticleDOI
Differential regulation of T-cell growth by IL-2 and IL-15.
Georgina H. Cornish,Georgina H. Cornish,Linda V. Sinclair,Linda V. Sinclair,Doreen A. Cantrell,Doreen A. Cantrell +5 more
TL;DR: The present results show that cytokines that are equivalent mitogens can have different potency in terms of regulating protein synthesis and cell growth.
Posted ContentDOI
Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans
Kevin W. Ng,Nikhil Faulkner,Georgina H. Cornish,Annachiara Rosa,Chris Earl,A.G. Wrobel,D.J. Benton,Chloe Roustan,William Bolland,Rachael Thompson,Ana Agua-Doce,Philip Hobson,Judith Heaney,Hannah Rickman,Stavroula Paraskevopoulou,Catherine F Houlihan,Kirsty Thomson,Emilie Sanchez,Gee Yen Shin,Moira J. Spyer,Philip A. Walker,Svend Kjaer,Andrew Riddell,Rupert Beale,Charles Swanton,Sonia Gandhi,Brigitta Stockinger,Steve Gamblin,Laura E. McCoy,Peter Cherepanov,Eleni Nastouli,George Kassiotis +31 more
TL;DR: The presence of pre-existing humoral immunity in uninfected and unexposed humans to the new coronavirus is demonstrated and identified as SARS-CoV-2 S-reactive antibodies, which were readily detectable by a sensitive flow cytometry-based method in SARS/COVID-19-uninfected individuals and were particularly prevalent in children and adolescents.
Journal ArticleDOI
Expression of transcription factor AML-2 (RUNX3, CBF(alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype.
TL;DR: The AML genes are the first example of cell transcription factors whose expression correlates with the latency I/III phenotype, and analysis of a panel of B-cell lines indicated that AML-2 expression is normally predominant in EBV latency III, whereasAML-1 is associated withEBV latency I or EBV-negative cells.