P
Philip A. Walker
Researcher at Francis Crick Institute
Publications - 47
Citations - 9087
Philip A. Walker is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Histone methyltransferase & Virus. The author has an hindex of 35, co-authored 46 publications receiving 8087 citations. Previous affiliations of Philip A. Walker include National Institute for Medical Research.
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Journal ArticleDOI
Structure of mammalian AMPK and its regulation by ADP
Bing Xiao,Matthew J. Sanders,Matthew J. Sanders,Elizabeth Underwood,Richard Heath,Faith V. Mayer,David Carmena,Chun-Xia Jing,Philip A. Walker,John F. Eccleston,Lesley F. Haire,Peter Saiu,Steven Howell,Rein Aasland,Stephen R. Martin,David Carling,Steven J. Gamblin +16 more
TL;DR: It is shown that ADP binding to just one of the two exchangeable AXP (AMP/ADP/ATP) binding sites on the regulatory domain protects the enzyme from dephosphorylation, although it does not lead to allosteric activation.
Journal ArticleDOI
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
David C. Goldstone,Valerie Ennis-Adeniran,Joseph J. Hedden,Harriet C. T. Groom,Gillian I. Rice,Evangelos Christodoulou,Philip A. Walker,Geoff Kelly,Lesley F. Haire,Melvyn W. Yap,Luiz Pedro S. de Carvalho,Jonathan P. Stoye,Yanick J. Crow,Ian A. Taylor,Michelle Webb +14 more
TL;DR: It is proposed that SAMHD1, which is highly expressed in dendritic cells, restricts HIV-1 replication by hydrolysing the majority of cellular dNTPs, thus inhibiting reverse transcription and viral complementary DNA (cDNA) synthesis.
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Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Kevin W. Ng,Nikhil Faulkner,Georgina H. Cornish,Annachiara Rosa,Ruth Harvey,Saira Hussain,Rachel Ulferts,Christopher Earl,A.G. Wrobel,D.J. Benton,Chloe Roustan,William Bolland,Rachael Thompson,Ana Agua-Doce,Philip Hobson,Judith Heaney,Hannah Rickman,Stavroula Paraskevopoulou,Catherine F Houlihan,Kirsty Thomson,Emilie Sanchez,Gee Yen Shin,Moira J. Spyer,Dhira Joshi,Nicola O’Reilly,Philip A. Walker,Svend Kjaer,Andrew Riddell,Catherine Moore,Bethany R. Jebson,Meredyth G. Ll Wilkinson,Lucy R. Marshall,Elizabeth C. Rosser,Anna Radziszewska,Hannah Peckham,Coziana Ciurtin,Lucy R. Wedderburn,Rupert Beale,Charles Swanton,Sonia Gandhi,Brigitta Stockinger,John W. McCauley,Steve Gamblin,Laura E. McCoy,Peter Cherepanov,Eleni Nastouli,George Kassiotis,George Kassiotis +47 more
TL;DR: Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, preexisting humoral immunity was detected and antibodies targeting the S2 subunit were particularly prevalent in children and adolescents.
Journal ArticleDOI
Structural basis for AMP binding to mammalian AMP-activated protein kinase
Bing Xiao,Richard Heath,Richard Heath,Peter Saiu,Fiona C. Leiper,Philippe Leone,Chun Jing,Philip A. Walker,Lesley F. Haire,John F. Eccleston,Colin T. Davis,Stephen R. Martin,David Carling,Steven J. Gamblin +13 more
TL;DR: The crystal structure of the regulatory fragment of mammalian AMPK in complexes with AMP and ATP is reported and suggests a mechanism for propagating AMP/ATP signalling whereby a phosphorylated residue from the α and/or β subunits binds to the γ subunit in the presence of AMP but not when ATP is bound.
Journal ArticleDOI
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.
Patrick J. Collins,Lesley F. Haire,Yi Pu Lin,Junfeng Liu,Rupert J. Russell,Philip A. Walker,John J. Skehel,Stephen R. Martin,Alan Hay,Steven J. Gamblin +9 more
TL;DR: The enzymatic properties and crystal structures of neuraminidase mutants from H5N1-infected patients are reported that explain the molecular basis of resistance and indicate that it would be prudent for pandemic stockpiles of oseltamivir to be augmented by additional antiviral drugs, including zanamivIR.