A
Annarosa Leri
Researcher at Brigham and Women's Hospital
Publications - 202
Citations - 40256
Annarosa Leri is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Stem cell & Myocyte. The author has an hindex of 88, co-authored 202 publications receiving 39365 citations. Previous affiliations of Annarosa Leri include Cardiovascular Institute of the South & University of Milan.
Papers
More filters
Journal ArticleDOI
Bone marrow cells regenerate infarcted myocardium
Donald Orlic,Jan Kajstura,Stefano Chimenti,Igor Jakoniuk,Stacie M. Anderson,Baosheng Li,James Pickel,Ronald D.G. McKay,Bernardo Nadal-Ginard,David M. Bodine,Annarosa Leri,Piero Anversa +11 more
TL;DR: It is indicated that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease.
Journal ArticleDOI
Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Antonio Paolo Beltrami,Laura Barlucchi,Daniele Torella,Mathue Baker,Federica Limana,Stefano Chimenti,Hideko Kasahara,Marcello Rota,Ezio Musso,Konrad Urbanek,Annarosa Leri,Jan Kajstura,Bernardo Nadal-Ginard,Piero Anversa +13 more
TL;DR: The existence of Lin(-) c-kit(POS) cells with the properties of cardiac stem cells, which are self-renewing, clonogenic, and multipotent, giving rise to myocytes, smooth muscle, and endothelial cells are reported.
Journal ArticleDOI
Mobilized bone marrow cells repair the infarcted heart, improving function and survival
Donald Orlic,Jan Kajstura,Stefano Chimenti,Federica Limana,Igor Jakoniuk,Federico Quaini,Bernardo Nadal-Ginard,David M. Bodine,Annarosa Leri,Piero Anversa +9 more
TL;DR: In this article, the authors demonstrate that transplanting primitive bone marrow cells (BMC) into the border zone of acute myocardial infarcts resulted in a significant degree of tissue regeneration 27 days later.
Journal ArticleDOI
Evidence That Human Cardiac Myocytes Divide after Myocardial Infarction
Antonio Paolo Beltrami,Konrad Urbanek,Jan Kajstura,Shaomin Yan,Nicoletta Finato,Rossana Bussani,Bernardo Nadal-Ginard,Silvestri F,Annarosa Leri,Carlo Alberto Beltrami,Piero Anversa +10 more
TL;DR: The results challenge the dogma that the adult heart is a postmitotic organ and indicate that the regeneration of myocytes may be a critical component of the increase in muscle mass of the myocardium.
Journal ArticleDOI
Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial.
Roberto Bolli,Atul R. Chugh,Domenico D'Amario,John H Loughran,Marcus F. Stoddard,Sohail Ikram,Garth M. Beache,Stephen G. Wagner,Annarosa Leri,Toru Hosoda,Fumihiro Sanada,Julius B Elmore,Polina Goichberg,Donato Cappetta,Naresh K Solankhi,Ibrahim Fahsah,D. Gregg Rokosh,Mark S. Slaughter,Jan Kajstura,Piero Anversa +19 more
TL;DR: It is suggested that intracoronary infusion of autologous CSCs is effective in improving LV systolic function and reducing infarct size in patients with heart failure after myocardial infarction, and warrant further, larger, phase 2 studies.