Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial.
Roberto Bolli,Atul R. Chugh,Domenico D'Amario,John H Loughran,Marcus F. Stoddard,Sohail Ikram,Garth M. Beache,Stephen G. Wagner,Annarosa Leri,Toru Hosoda,Fumihiro Sanada,Julius B Elmore,Polina Goichberg,Donato Cappetta,Naresh K Solankhi,Ibrahim Fahsah,D. Gregg Rokosh,Mark S. Slaughter,Jan Kajstura,Piero Anversa +19 more
Reads0
Chats0
TLDR
It is suggested that intracoronary infusion of autologous CSCs is effective in improving LV systolic function and reducing infarct size in patients with heart failure after myocardial infarction, and warrant further, larger, phase 2 studies.About:
This article is published in The Lancet.The article was published on 2011-11-26 and is currently open access. It has received 1312 citations till now. The article focuses on the topics: Ischemic cardiomyopathy & Ejection fraction.read more
Citations
More filters
Journal ArticleDOI
2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction
Patrick T. O'Gara,Frederick G. Kushner,Deborah D. Ascheim,Donald E. Casey,Mina K. Chung,James A. de Lemos,Steven M. Ettinger,James C. Fang,Francis M. Fesmire,Barry A. Franklin,Christopher B. Granger,Harlan M. Krumholz,Jane A. Linderbaum,David A. Morrow,L. Kristin Newby,Joseph P. Ornato,Narith N. Ou,Martha J. Radford,Jacqueline E. Tamis-Holland,Carl L. Tommaso,Cynthia M. Tracy,Y. Joseph Woo,David Zhao +22 more
TL;DR: The 2017-18 FAHA/FACC/FAHA Education and Research Grants will be focused on advancing the profession’s understanding of central nervous system disorders and the management of post-traumatic stress disorder.
Journal ArticleDOI
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
Raj Makkar,Rachel Ruckdeschel Smith,Ke Cheng,Konstantinos Malliaras,Louise Thomson,Daniel S. Berman,Lawrence S.C. Czer,Linda Marbán,Adam Mendizabal,Peter V. Johnston,Stuart D. Russell,Karl H. Schuleri,Albert C. Lardo,Gary Gerstenblith,Eduardo Marbán +14 more
TL;DR: In this paper, Cardiosphere-derived cells (CDCs) were used to reduce scarring after myocardial infarction, increase viable myocardium, and boost cardiac function in preclinical models.
Journal ArticleDOI
Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: The POSEIDON randomized trial
Joshua M. Hare,Joel E. Fishman,Gary Gerstenblith,Darcy L. Velazquez,Juan P. Zambrano,Viky Y Suncion,Melissa Tracy,Eduard Ghersin,Peter V. Johnston,Jeffrey A. Brinker,Elayne Breton,Janice Davis-Sproul,Ivonne Hernandez Schulman,Ivonne Hernandez Schulman,John J. Byrnes,Adam Mendizabal,Maureen H. Lowery,Didier Rouy,Peter A. Altman,Cheryl Wong Po Foo,Phillip Ruiz,Alexandra Amador,José Paulo da Silva,Ian McNiece,Ian McNiece,Alan W. Heldman +25 more
TL;DR: In this early-stage study of patients with ICM, transendocardial injection of allogeneic and autologous MSCs without a placebo control were both associated with low rates of treatment-emergent SAEs, including immunologic reactions.
Journal ArticleDOI
The inflammatory response in myocardial injury, repair, and remodelling.
TL;DR: Biomarker-based approaches are needed to identify patients with distinct pathophysiologic responses and to rationally implement inflammation-modulating strategies in patients with myocardial infarction.
Journal ArticleDOI
Functional screening identifies miRNAs inducing cardiac regeneration
Ana Eulalio,Miguel Mano,Matteo Dal Ferro,Matteo Dal Ferro,Lorena Zentilin,Gianfranco Sinagra,Serena Zacchigna,Mauro Giacca +7 more
TL;DR: It is shown that the exogenous administration of selected microRNAs (miRNAs) markedly stimulates cardiomyocyte proliferation and promotes cardiac repair and the miRNAs identified hold great promise for the treatment of cardiac pathologies consequent to cardiomeocyte loss.
References
More filters
Journal ArticleDOI
Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms.
Nelson B. Schiller,P. M. Shah,Michael H. Crawford,Anthony N. DeMaria,Richard B. Devereux,Harvey Feigenbaum,H. Gutgesell,Nathaniel Reichek,David J. Sahn,Ingela Schnittger +9 more
TL;DR: It is the opinion that current technology justifies the clinical use of the quantitative two-dimensional methods described in this article and the routine reporting of left ventricular ejection fraction, diastolic volume, mass, and wall motion score.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2011 Update A Report From the American Heart Association
Véronique L. Roger,Alan S. Go,Donald M. Lloyd-Jones,Robert J. Adams,Jarett D. Berry,Todd M. Brown,Mercedes R. Carnethon,Shifan Dai,Giovanni de Simone,Earl S. Ford,Caroline S. Fox,Heather J. Fullerton,Cathleen Gillespie,Kurt J. Greenlund,Susan M. Hailpern,John A. Heit,P. Michael Ho,Virginia J. Howard,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Judith H. Lichtman,Lynda D. Lisabeth,Diane M. Makuc,Gregory M. Marcus,Ariane Marelli,David B. Matchar,Mary M. McDermott,James B. Meigs,Claudia S. Moy,Dariush Mozaffarian,Michael E. Mussolino,Graham Nichol,Nina P. Paynter,Wayne D. Rosamond,Paul D. Sorlie,Randall S. Stafford,Tanya N. Turan,Melanie B. Turner,Nathan D. Wong,Judith Wylie-Rosett +40 more
TL;DR: Dariush Mozaffarian, Michael E. Mussolino, Graham Nichol, Nina P. Paynter, Wayne D. Sorlie, Randall S. Stafford, Tanya N. Turan, Melanie B. Turner, Nathan D. Turner.
Journal ArticleDOI
Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Antonio Paolo Beltrami,Laura Barlucchi,Daniele Torella,Mathue Baker,Federica Limana,Stefano Chimenti,Hideko Kasahara,Marcello Rota,Ezio Musso,Konrad Urbanek,Annarosa Leri,Jan Kajstura,Bernardo Nadal-Ginard,Piero Anversa +13 more
TL;DR: The existence of Lin(-) c-kit(POS) cells with the properties of cardiac stem cells, which are self-renewing, clonogenic, and multipotent, giving rise to myocytes, smooth muscle, and endothelial cells are reported.
Journal ArticleDOI
Transcoronary transplantation of progenitor cells after myocardial infarction.
Birgit Assmus,Jörg Honold,Volker Schächinger,Martina B. Britten,Ulrich Fischer-Rasokat,Ralf Lehmann,Claudius Teupe,Katrin Pistorius,Hans Martin,Nasreddin Abolmaali,Torsten Tonn,Stefanie Dimmeler,Andreas M. Zeiher +12 more
TL;DR: Intracoronary infusion of progenitor cells is safe and feasible in patients with healed myocardial infarction and is associated with moderate but significant improvement in the left ventricular ejection fraction after 3 months.
Journal ArticleDOI
More ‘malignant’ than cancer? Five‐year survival following a first admission for heart failure
TL;DR: The prognostic impact of heart failure relative to that of ‘high‐profile’ disease states such as cancer, within the whole population, is unknown.