A
Anne Lise Børresen-Dale
Researcher at Oslo University Hospital
Publications - 470
Citations - 94317
Anne Lise Børresen-Dale is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 104, co-authored 456 publications receiving 83276 citations. Previous affiliations of Anne Lise Børresen-Dale include University of Oslo & Vanderbilt University.
Papers
More filters
Journal ArticleDOI
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
Tiffany Hung,Yulei Wang,Michael F. Lin,Michael F. Lin,Ashley K. Koegel,Yojiro Kotake,Yojiro Kotake,Gavin D. Grant,Hugo M. Horlings,Nilay Shah,Christopher B. Umbricht,Pei Wang,Yu Wang,Benjamin Kong,Anita Langerød,Anne Lise Børresen-Dale,Seung K. Kim,Marc J. van de Vijver,Saraswati Sukumar,Michael L. Whitfield,Manolis Kellis,Manolis Kellis,Yue Xiong,David J. Wong,Howard Y. Chang +24 more
TL;DR: In this article, an ultra-high-density array that tiles the promoters of 56 cell-cycle genes was used to interrogate 108 samples representing diverse perturbations, identifying 216 transcribed regions that encode putative lncRNAs, many with RT-PCR-validated periodic expression during the cell cycle.
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
Tiffany Hung,Yulei Wang,Michael F. Lin,Michael F. Lin,Ashley K. Koegel,Yojiro Kotake,Yojiro Kotake,Gavin D. Grant,Hugo M. Horlings,Nilay Shah,Christopher B. Umbricht,Pei Wang,Yu Wang,Benjamin Kong,Anita Langerød,Anne Lise Børresen-Dale,Seung K. Kim,Marc J. van de Vijver,Saraswati Sukumar,Michael L. Whitfield,Manolis Kellis,Manolis Kellis,Yue Xiong,David J. Wong,Howard Y. Chang +24 more
TL;DR: This work uses an ultrahigh-density array that tiles the promoters of 56 cell-cycle genes to interrogate 108 samples representing diverse perturbations and identifies 216 transcribed regions that encode putative lncRNAs, many with RT-PCR–validated periodic expression during the cell cycle.
Journal ArticleDOI
Complex landscapes of somatic rearrangement in human breast cancer genomes.
Philip J. Stephens,David J. McBride,Meng-Lay Lin,Ignacio Varela,Erin Pleasance,Jared T. Simpson,Lucy Stebbings,Catherine Leroy,Sarah Edkins,Laura Mudie,Christopher Greenman,Mingming Jia,Calli Latimer,Jon W. Teague,King Wai Lau,John Burton,Michael A. Quail,Harold Swerdlow,Carol Churcher,Rachael Natrajan,Anieta M. Sieuwerts,John W.M. Martens,Daniel P. Silver,Anita Langerød,Hege G. Russnes,John A. Foekens,Jorge S. Reis-Filho,Laura van 't Veer,Andrea L. Richardson,Anne Lise Børresen-Dale,Peter J. Campbell,P. Andrew Futreal,Michael R. Stratton,Michael R. Stratton +33 more
TL;DR: A paired-end sequencing strategy is used to identify somatic rearrangements in breast cancer genomes and provides a new perspective on cancer genomes, highlighting the diversity of somatic upheavals and their potential contribution to cancer development.
Journal ArticleDOI
TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes
TL;DR: It is shown that intrinsic mutagenicity rates, loss of transactivation activities, and to a lesser extent, dominant-negative activities are the main driving forces that determine TP53 mutation patterns and influence tumor phenotype.
Journal ArticleDOI
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
William A. Freed-Pastor,Hideaki Mizuno,Xi Zhao,Anita Langerød,Sung Hwan Moon,Ruth Rodriguez-Barrueco,Anthony M. Barsotti,Agustin Chicas,Wencheng Li,Alla Polotskaia,Mina J. Bissell,Timothy F. Osborne,Bin Tian,Scott W. Lowe,Jose M. Silva,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Arnold J. Levine,Jill Bargonetti,Carol Prives +19 more
TL;DR: It is found that mutant p53 depletion is sufficient to phenotypically revert breast cancer cells to a more acinar-like morphology, which implicate the mevalonate pathway as a therapeutic target for tumors bearing mutations in p53.