The CD95 receptor: apoptosis revisited.
Marcus E. Peter,Ralph C. Budd,Julie Desbarats,Stephen M. Hedrick,Anne-Odile Hueber,M. Karen Newell,Laurie B. Owen,Richard M. Pope,Juerg Tschopp,Harald Wajant,David Wallach,Robert H. Wiltrout,Martin Zörnig,David H. Lynch +13 more
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TLDR
Evidence suggests that CD95 mediates not only apoptosis but also diverse nonapoptotic functions depending on the tissue and the conditions.About:
This article is published in Cell.The article was published on 2007-05-04 and is currently open access. It has received 396 citations till now. The article focuses on the topics: Fas receptor & Signal transduction.read more
Citations
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Journal ArticleDOI
The Many Roles of FAS Receptor Signaling in the Immune System
TL;DR: Current understanding of Fas-induced apoptosis signaling is described and experimental strategies for future advances are proposed.
Journal ArticleDOI
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Lorenzo Galluzzi,J M Bravo-San Pedro,Ilio Vitale,Stuart A. Aaronson,John M. Abrams,Dieter Adam,Emad S. Alnemri,Lucia Altucci,David W. Andrews,Margherita Annicchiarico-Petruzzelli,Eric H. Baehrecke,Nicolas G. Bazan,Mathieu J.M. Bertrand,Mathieu J.M. Bertrand,Katiuscia Bianchi,Katiuscia Bianchi,Mikhail V. Blagosklonny,Klas Blomgren,Christoph Borner,Dale E. Bredesen,Dale E. Bredesen,Catherine Brenner,Catherine Brenner,Michelangelo Campanella,Eleonora Candi,Francesco Cecconi,Francis Ka-Ming Chan,Navdeep S. Chandel,Emily H. Cheng,Jerry E. Chipuk,John A. Cidlowski,Aaron Ciechanover,Ted M. Dawson,Valina L. Dawson,V De Laurenzi,R De Maria,Klaus-Michael Debatin,N. Di Daniele,Vishva M. Dixit,Brian David Dynlacht,Wafik S. El-Deiry,Gian Maria Fimia,Richard A. Flavell,Simone Fulda,Carmen Garrido,Marie-Lise Gougeon,Douglas R. Green,Hinrich Gronemeyer,György Hajnóczky,J M Hardwick,Michael O. Hengartner,Hidenori Ichijo,Bertrand Joseph,Philipp J. Jost,Thomas Kaufmann,Oliver Kepp,Daniel J. Klionsky,Richard A. Knight,Richard A. Knight,Sharad Kumar,Sharad Kumar,John J. Lemasters,Beth Levine,Beth Levine,Andreas Linkermann,Stuart A. Lipton,Richard A. Lockshin,Carlos López-Otín,Enrico Lugli,Frank Madeo,Walter Malorni,Jean-Christophe Marine,Seamus J. Martin,J-C Martinou,Jan Paul Medema,Pascal Meier,Sonia Melino,Noboru Mizushima,Ute M. Moll,Cristina Muñoz-Pinedo,Gabriel Núñez,Andrew Oberst,Theocharis Panaretakis,Josef M. Penninger,Marcus E. Peter,Mauro Piacentini,Paolo Pinton,Jochen H. M. Prehn,Hamsa Puthalakath,Gabriel A. Rabinovich,Kodi S. Ravichandran,Rosario Rizzuto,Cecília M. P. Rodrigues,David C. Rubinsztein,Thomas Rudel,Yufang Shi,Hans-Uwe Simon,Brent R. Stockwell,Brent R. Stockwell,Gyorgy Szabadkai,Gyorgy Szabadkai,Stephen W.G. Tait,H. L. Tang,Nektarios Tavernarakis,Nektarios Tavernarakis,Yoshihide Tsujimoto,T Vanden Berghe,T Vanden Berghe,Peter Vandenabeele,Peter Vandenabeele,Andreas Villunger,Erwin F. Wagner,Henning Walczak,Eileen White,W. G. Wood,Junying Yuan,Zahra Zakeri,Boris Zhivotovsky,Boris Zhivotovsky,Gerry Melino,Gerry Melino,Guido Kroemer +121 more
TL;DR: The Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.
Journal ArticleDOI
Death receptor signal transducers: nodes of coordination in immune signaling networks.
TL;DR: Together with other DR signal transducers, FADD and TRADD participate in functional complexes assembled by certain non-DR immune cell receptors, such as pattern-recognition receptors, which may provide important nodes of coordination in immune signaling networks.
Journal ArticleDOI
XIAP discriminates between type I and type II FAS-induced apoptosis
Philipp J. Jost,Stephanie Grabow,Stephanie Grabow,Daniel H.D. Gray,Mark D. McKenzie,Mark D. McKenzie,Ulrich Nachbur,David C.S. Huang,Philippe Bouillet,Helen E. Thomas,Christoph Borner,John Silke,Andreas Strasser,Thomas Kaufmann,Thomas Kaufmann +14 more
TL;DR: The results show that XIAP is the critical discriminator between type I and type II apoptosis signalling and suggest that IAP inhibitors should be used with caution in cancer patients with underlying liver conditions.
Journal ArticleDOI
FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR
Trever G. Bivona,Haley Hieronymus,Joel S. Parker,Kenneth Chang,Miquel Taron,Rafael Rosell,Philicia Moonsamy,Kimberly B. Dahlman,Vincent A. Miller,Carlota Costa,Gregory J. Hannon,Gregory J. Hannon,Charles L. Sawyers,Charles L. Sawyers +13 more
TL;DR: NF-κB is identified as a potential companion drug target, together with EGFR, in EGFR-mutant lung cancers and insight is provided into the mechanisms by which tumour cells escape from oncogene dependence.
References
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Journal ArticleDOI
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.
Nils Holler,Rossana Zaru,Olivier Micheau,Margot Thome,Antoine Attinger,Salvatore Valitutti,Jean-Luc Bodmer,Pascal Schneider,Brian Seed,Jürg Tschopp +9 more
TL;DR: F Fas kills activated primary T cells efficiently in the absence of active caspases, which results in necrotic morphological changes and late mitochondrial damage but no cytochrome c release.
Journal ArticleDOI
The CD95(APO-1/Fas) DISC and beyond
Marcus E. Peter,Peter H. Krammer +1 more
TL;DR: A number of proteins have been reported to regulate formation or activity of the DISC, the complex of proteins that forms upon triggering of CD95 that is essential for induction of apoptosis.
Journal ArticleDOI
Not just a sink: endosomes in control of signal transduction.
TL;DR: By deciphering the interplay between endocytosis and signalling, this work will be able to gain a more sophisticated level of understanding of signal transduction mechanisms.
Journal ArticleDOI
Fas transduces activation signals in normal human T lymphocytes.
Mark R. Alderson,R J Armitage,Eugene Maraskovsky,T W Tough,E Roux,K A Schooley,Fred Ramsdell,David H. Lynch +7 more
TL;DR: The data demonstrate that in addition to a role in the induction of apoptosis in certain transformed cell lines, the Fas protein may also play an important role inThe activation and proliferation of normal T cells.
Journal ArticleDOI
Dendritic cell apoptosis in the maintenance of immune tolerance.
Min Chen,Yui-Hsi Wang,Yui-Hsi Wang,Yi-Hong Wang,Yi-Hong Wang,Li Huang,Li Huang,Hector Sandoval,Yong-Jun Liu,Yong-Jun Liu,Jin Wang +10 more
TL;DR: The observation that a defect in DC apoptosis can independently lead to autoimmunity is consistent with a central role for these cells in maintaining immune self-tolerance.