M
M. Karen Newell
Researcher at University of Colorado Colorado Springs
Publications - 16
Citations - 1058
M. Karen Newell is an academic researcher from University of Colorado Colorado Springs. The author has contributed to research in topics: Fatty acid metabolism & Etomoxir. The author has an hindex of 10, co-authored 16 publications receiving 1028 citations. Previous affiliations of M. Karen Newell include University of Colorado Denver & University of Colorado Boulder.
Papers
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Journal ArticleDOI
The CD95 receptor: apoptosis revisited.
Marcus E. Peter,Ralph C. Budd,Julie Desbarats,Stephen M. Hedrick,Anne-Odile Hueber,M. Karen Newell,Laurie B. Owen,Richard M. Pope,Juerg Tschopp,Harald Wajant,David Wallach,Robert H. Wiltrout,Martin Zörnig,David H. Lynch +13 more
TL;DR: Evidence suggests that CD95 mediates not only apoptosis but also diverse nonapoptotic functions depending on the tissue and the conditions.
Journal ArticleDOI
Fas engagement induces neurite growth through ERK activation and p35 upregulation.
Julie Desbarats,Julie Desbarats,Julie Desbarats,Raymond B. Birge,Raymond B. Birge,Manuelle Mimouni-Rongy,David E. Weinstein,Jean-Sébastien Palerme,M. Karen Newell +8 more
TL;DR: It is reported that crosslinking Fas on primary sensory neurons induces neurite growth through sustained activation of the extracellular-signal regulated kinase (ERK) pathway and the consequent upregulation of p35, a mediator of neurite outgrowth.
Journal ArticleDOI
Characterization of a novel metabolic strategy used by drug-resistant tumor cells
Mary-Ellen Harper,Andreas Antoniou,Elizabeth Villalobos-Menuey,Alicia Russo,Richard Trauger,Minda Vendemelio,Amanda M George,Richard M. Bartholomew,Dennis J. Carlo,Azhar M. Shaikh,Jami Kupperman,Evan W. Newell,Ivan A. Bespalov,Susan S. Wallace,Ye Liu,Jeffrey R Rogers,Gregory L. Gibbs,Jack L. Leahy,Robert E. Camley,Robert J. Melamede,Robert J. Melamede,M. Karen Newell +21 more
TL;DR: It is shown that drug‐resistant cells have low mitochondrial membrane potential, use nonglucose carbon sources (fatty acids) for mitochondrial oxygen consumption when glucose becomes limited, and are protected from exogenous stress such as radiation.
Patent
Systems and methods for treating human inflammatory and proliferative diseases and wounds, with fatty acid metabolism inhibitors and/or glycolytic inhibitors
TL;DR: In this paper, the authors proposed a system and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a fatty acid metabolism inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherpeutic agents.
Journal ArticleDOI
Cellular metabolism as a basis for immune privilege
M. Karen Newell,Elizabeth Villalobos-Menuey,Susan C Schweitzer,Mary-Ellen Harper,Robert E. Camley +4 more
TL;DR: It is proposed that the cell's ability to switch to, and efficiently use, fat for fuel confers immune privilege, and because uncoupling proteins are involved in the fat burning process and reportedly in protection from free radicals, it is hypothesized that uncoupled proteins play an important role in immune privilege.