A
Antoine E. Karnoub
Researcher at Harvard University
Publications - 41
Citations - 6934
Antoine E. Karnoub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 23, co-authored 37 publications receiving 6407 citations. Previous affiliations of Antoine E. Karnoub include Massachusetts Institute of Technology & University of North Carolina at Chapel Hill.
Papers
More filters
Journal ArticleDOI
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Antoine E. Karnoub,Ajeeta B. Dash,Annie P. Vo,Andrew J. Sullivan,Mary W. Brooks,George W. Bell,Andrea L. Richardson,Kornelia Polyak,Ross Tubo,Robert A. Weinberg +9 more
TL;DR: It is demonstrated that bone-marrow-derived human mesenchymal stem cells, when mixed with otherwise weakly metastatic human breast carcinoma cells, cause the cancer cells to increase their metastatic potency greatly when this cell mixture is introduced into a subcutaneous site and allowed to form a tumour xenograft.
Journal ArticleDOI
Ras oncogenes: split personalities
TL;DR: Despite great strides in understanding of the molecular and cellular mechanisms of action of the Ras proteins, the expanding roster of their downstream effectors and the complexity of the signalling cascades that they regulate indicate that much remains to be learnt.
Journal ArticleDOI
Distinct requirements for Ras oncogenesis in human versus mouse cells
Nesrin M Hamad,Joel H. Elconin,Antoine E. Karnoub,Wenli Bai,Jeremy N. Rich,Robert T. Abraham,Robert T. Abraham,Channing J. Der,Christopher M. Counter +8 more
TL;DR: Using oncogenic Ras mutants that activate single effectors as well as constitutively active effectors, it is found that the RalGEF, and not the Raf or PI3-kinase pathway, is sufficient for Ras transformation in human cells.
Journal ArticleDOI
Transformation of Different Human Breast Epithelial Cell Types Leads to Distinct Tumor Phenotypes
Tan A. Ince,Andrea L. Richardson,Andrea L. Richardson,George W. Bell,Maki Saitoh,Samuel Godar,Antoine E. Karnoub,James Dirk Iglehart,Robert A. Weinberg +8 more
TL;DR: Compared tumors derived from two different normal human mammary epithelial cell populations, one of which was isolated using a new culture medium, found that the pre-existing differences between BPECs and HMECs strongly influence the phenotypes of their transformed derivatives.
Journal ArticleDOI
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation
TL;DR: Surprisingly, it is found that Rac1b, like the constitutively-activated and transforming Rac1(Q61L) mutant, promoted growth transformation of NIH3T3 cells and selectively activates a subset of Rac1 downstream signaling pathways to facilitate cellular transformation.