P
Philip J. Uren
Researcher at University of Southern California
Publications - 26
Citations - 1609
Philip J. Uren is an academic researcher from University of Southern California. The author has contributed to research in topics: RNA-binding protein & Cellular differentiation. The author has an hindex of 18, co-authored 26 publications receiving 1330 citations. Previous affiliations of Philip J. Uren include University of Tasmania.
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Journal ArticleDOI
Directional DNA Methylation Changes and Complex Intermediate States Accompany Lineage Specificity in the Adult Hematopoietic Compartment
Emily Hodges,Antoine Molaro,Antoine Molaro,Camila O. dos Santos,Camila O. dos Santos,Pramod Thekkat,Pramod Thekkat,Qiang Song,Philip J. Uren,Jin Park,Jason M. Butler,Jason M. Butler,Shahin Rafii,Shahin Rafii,W. Richard McCombie,Andrew D. Smith,Gregory J. Hannon,Gregory J. Hannon +17 more
TL;DR: In this paper, the authors characterized the methylomes of human female hematopoietic stem/progenitor cells (HSPCs) and mature cells from the myeloid and lymphoid lineages.
Journal ArticleDOI
Site identification in high-throughput RNA–protein interaction data
Philip J. Uren,Emad Bahrami-Samani,Suzanne C. Burns,Mei Qiao,Fedor V. Karginov,Emily Hodges,Gregory J. Hannon,Jeremy R. Sanford,Luiz O. F. Penalva,Andrew D. Smith +9 more
TL;DR: This work introduces a method for site identification which can be applied on all variations of CLIP and RIP-seq technologies, and accurately models the underlying read-count distributions, and allows external covariates, such as transcript abundance, to inform the site identification process.
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WTAP is a novel oncogenic protein in acute myeloid leukemia
Hima Bansal,Q. Yihua,Swami P. Iyer,Suthakar Ganapathy,David A. Proia,Luiz O. F. Penalva,Philip J. Uren,Uthra Suresh,Jennifer S. Carew,Anand B. Karnad,Steven D. Weitman,Gail E. Tomlinson,Manjeet K. Rao,Steve Kornblau,Sanjay Bansal +14 more
TL;DR: Results provide evidence for an association between the increased expression of WTAP and chemoresistance in AML, and the in vitro transforming activity ofWTAP was examined by investigating its effects on growth of the Ba/F3 cell line.
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Aberrant sperm DNA methylation predicts male fertility status and embryo quality
Kenneth I. Aston,Philip J. Uren,Timothy G. Jenkins,Alan Horsager,Bradley R. Cairns,Bradley R. Cairns,Andrew D. Smith,Douglas T. Carrell +7 more
TL;DR: Predictive models proved to be highly accurate in classifying male fertility status (fertile or infertile), with 82% sensitivity, and 99% positive predictive value, and DNA methylation patterns may be predictive of embryo quality during IVF.
Journal ArticleDOI
Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sites.
Philip J. Uren,Suzanne C. Burns,Jianhua Ruan,Kusum Kumari Singh,Andrew D. Smith,Luiz O. F. Penalva +5 more
TL;DR: The results reveal the complexity of RBP binding, corroborate the concept of post-transcriptional networks and suggest an interplay between miRNAs and RBPs.