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Archibald S. Perkins
Researcher at University of Rochester Medical Center
Publications - 73
Citations - 4642
Archibald S. Perkins is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Haematopoiesis & Myeloid leukemia. The author has an hindex of 32, co-authored 73 publications receiving 4326 citations. Previous affiliations of Archibald S. Perkins include University of Alberta & Boston Children's Hospital.
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Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.
Camilynn I. Brannan,Archibald S. Perkins,Kristine S. Vogel,Nancy Ratner,Michael L. Nordlund,Susan W. Reid,Arthur M. Buchberg,Nancy A. Jenkins,Luis F. Parada,Neal G. Copeland +9 more
TL;DR: These results identify new roles for NF1 in development and indicate that some of the abnormal growth phenomena observed in NF1 patients can be recapitulated in neurofibromin-deficient mice.
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Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
Scott C. Kogan,Jerrold M. Ward,Miriam R. Anver,Jules J. Berman,Cory Brayton,Robert D. Cardiff,John S. Carter,Sherri de Coronado,James R. Downing,Torgny N. Fredrickson,Diana C. Haines,Alan W. Harris,Nancy L. Harris,Hiroshi Hiai,Elaine S. Jaffe,Ian C. M. MacLennan,Pier Paolo Pandolfi,Paul K. Pattengale,Archibald S. Perkins,R. Mark Simpson,Mark S. Tuttle,Joanne F. Wong,Herbert C. Morse +22 more
TL;DR: This classification will be of particular value to investigators seeking to develop, use, and communicate about mouse models of human hematopoietic neoplasms in order to diagnose lesions as well-defined entities according to accepted criteria.
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Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop.
TL;DR: Examination of c-myc expression in mutant embryos indicates the existence of coordinate regulation of myc genes during mouse embryogenesis and suggests further that there are linked regulatory mechanisms for normal expression in the embryo.
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Vaccination with a Recombinant Vesicular Stomatitis Virus Expressing an Influenza Virus Hemagglutinin Provides Complete Protection from Influenza Virus Challenge
Anjeanette Roberts,Evelyne Kretzschmar,Archibald S. Perkins,John P. Forman,Ryan Price,Linda Buonocore,Yoshihiro Kawaoka,John K. Rose +7 more
TL;DR: VSV-HA is an effective intranasal vaccine vector that raises high levels of neutralizing antibody to influenza virus and completely protects mice from bronchial pneumonia caused by challenge with a lethal dose of influenza A virus.
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Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression
Hiromi Yuasa,Yuichi Oike,Atsushi Iwama,Ichiro Nishikata,Daisuke Sugiyama,Archibald S. Perkins,Michael L. Mucenski,Toshio Suda,Kazuhiro Morishita +8 more
TL;DR: It is shown that Evi1 is predominantly expressed in hematopoietic stem cells (HSCs) in embryos and adult bone marrows, suggesting a physiological role of Evi 1 in HSCs, and that transcription factors regulate the HSC pool hierarchically.