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Arnold L. Demain
Researcher at Drew University
Publications - 425
Citations - 21576
Arnold L. Demain is an academic researcher from Drew University. The author has contributed to research in topics: Streptomyces clavuligerus & Clostridium thermocellum. The author has an hindex of 66, co-authored 424 publications receiving 20140 citations. Previous affiliations of Arnold L. Demain include Massachusetts Institute of Technology & Merck & Co..
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Regulation of biosynthesis of bacilysin by Bacillus subtilis.
TL;DR: Production of the dipeptide antibiotic bacilysin by Bacillus subtilis 168 was growth associated and showed no evidence of repression by glucose or sucrose, and aspartate was slightly better than glutamate for antibiotic production as sole nitrogen source.
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Antimicrobial spectrum of the antitumor agent, cisplatin.
Kellie Joyce,Shruti Saxena,Amanda Williams,Christopher Damurjian,Neil Auricchio,Sabrina Aluotto,Heather Tynan,Arnold L. Demain +7 more
TL;DR: The antimicrobial spectrum of cisplatin was determined to expand the screening effort to include more filamentous fungi, as there has been very little screening effort focusing on the molds.
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Methionine induction of ACV synthetase in Cephalosporium acremonium
TL;DR: Direct measurement of ACV synthetase activity in a cell-free system indicated that the methionine effect was mainly due to induction of this first enzyme of the β-lactam biosynthetic pathway, resulting in a corresponding increase in β- lactam production in both a low-producing strain and a high-producing mutant.
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Phosphate regulation of ACV synthetase and cephalosporin biosynthesis in Streptomyces clavuligerus
TL;DR: Cephalosporin production by Streptomyces clavuligerus was reduced sharply by 60 mM phosphate added to a chemically-defined medium and all the four synthetases in the pathway examined were repressed by phosphate, with ACV synthetase being the main repression target and expandase the next.
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Repression and inhibition of cephalosporin synthetases in Streptomyces clavuligerus by inorganic phosphate
TL;DR: Cephalosporin production by growing cells of Streptomyces clavuligerus was reduced by 100 mM inorganic phosphate and cell-free activity of desacetoxycephalosporIn C synthetase (ring expansion activity) was repressed by prior growth in high phosphate and inhibited by phosphate.