A
Arnold L. Demain
Researcher at Drew University
Publications - 425
Citations - 21576
Arnold L. Demain is an academic researcher from Drew University. The author has contributed to research in topics: Streptomyces clavuligerus & Clostridium thermocellum. The author has an hindex of 66, co-authored 424 publications receiving 20140 citations. Previous affiliations of Arnold L. Demain include Massachusetts Institute of Technology & Merck & Co..
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Effective levels of tetanus toxin can be made in a production medium totally lacking both animal (e.g., brain heart infusion) and dairy proteins or digests (e.g., casein hydrolysates).
TL;DR: A fermentation medium for Clostridium tetani is developed that results in the formation of tetanus toxin and contains no meat or dairy products, thus obviating the problem of possible prion diseases.
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Mollicellins: mutagenic and antibacterial mycotoxins.
TL;DR: Eight mollicellins were assayed for mutagenicity and antibacterial activity in Salmonella/microsome tests involving histidine reversion and forward mutation to 8-azaguanine resistance and the mutagenic activity was completely abolished and the antibiotic activity was greatly reduced by coincubation with rat liver microsomes.
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Alternate requirement for vitamin B12 or methionine in mutants of Pseudomonas denitrificans, a vitamin B12-producing bacterium.
Barbara D. Lago,Arnold L. Demain +1 more
TL;DR: Experiments are described which indicate that Pseudomonas denitrificans, an organism that overproduces vitamin B(12), uses the B( 12) pathway exclusively for methionine synthesis.
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Germination initiation and outgrowth of spores of Bacillus brevis strain Nagano and its gramicidin S-negative mutant.
TL;DR: A mechanism of action for gramicidin S whereby it interferes in membrane function, such as transport or energy metabolism, in outgrowing spores is suggested.
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Sporulation and Spore Properties of Bacillus brevis and its Gramicidin S-negative Mutant
TL;DR: Spore properties in mature parental and mutant spores were equally resistant to UV irradiation, solvents and heat, and the lack of gramicidin S synthesis impairs none of these properties.