A
Arnold L. Demain
Researcher at Drew University
Publications - 425
Citations - 21576
Arnold L. Demain is an academic researcher from Drew University. The author has contributed to research in topics: Streptomyces clavuligerus & Clostridium thermocellum. The author has an hindex of 66, co-authored 424 publications receiving 20140 citations. Previous affiliations of Arnold L. Demain include Massachusetts Institute of Technology & Merck & Co..
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Cell-free cyclization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N.
TL;DR: It is found that sonication can be used directly to prepare extracts with cyclization activity from mycelia, without preparing protoplast lysates, and the kinetics of cyclase appearance and disappearance during fermentation were similar to those of ring-expansion activity.
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Microbial Degradation of Cephalosporin C
TL;DR: It is found that these two enzymatic activities are present in many bacteria and actinomycetes but not in the moulds examined.
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Antibiotics: Natural Products Essential to Human Health
TL;DR: For more than 50 years, natural products of microorganisms have served us well in combating infectious bacteria and fungi as discussed by the authors, and many of the major pharmaceutical companies have abandoned the antibiotic field leaving much of the discovery efforts to small companies, new companies, and the biotechnology industries.
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Secondary metabolism in simulated microgravity: beta-lactam production by Streptomyces clavuligerus.
TL;DR: Rotating bioreactors designed at NASA’s Johnson Space Center were used to simulate a microgravity environment in which to study secondary metabolism and the degree of β-lactam antibiotic production was markedly inhibited by simulated microgravity.