A
Arnold L. Demain
Researcher at Drew University
Publications - 425
Citations - 21576
Arnold L. Demain is an academic researcher from Drew University. The author has contributed to research in topics: Streptomyces clavuligerus & Clostridium thermocellum. The author has an hindex of 66, co-authored 424 publications receiving 20140 citations. Previous affiliations of Arnold L. Demain include Massachusetts Institute of Technology & Merck & Co..
Papers
More filters
Journal ArticleDOI
Use of controlled-release polymer to feed ammonium to Streptomyces clavuligerus cephalosporin fermentations in shake flasks
TL;DR: Controlled-release polymers containing NH4Cl were used to feed Streptomyces clavuligerus cultures making cephalosporins in shake flasks, and production approached the performance of l-asparagine, the best single nitrogen source for production.
Patent
Method for production of tetanus toxin using media substantially free of animal products
Arnold L. Demain,Aigi Fang +1 more
TL;DR: In this paper, a system for the growth of C.tetani and production of Tetanus Toxin for use in formulating Tetanus toxoid preparations is presented.
Journal ArticleDOI
EFFECT OF AMMONIUM AS NITROGEN SOURCE ON PRODUCTION OF δ(L-α-AMINOADIPLY)-L-CYSTEINYL-D-VALINE SYNTHETASE BY CEPHALOSPORIUM ACREMONIUM C-10
TL;DR: Ammonium repression was exerted on formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) synthetase, together with that of expandase; a lesser effect by ammonium was observed on cyclase production.
Journal ArticleDOI
High performance liquid chromatography (HPLC) of natural products V. The use of HPLC in the cell-free biosynthetic conversion of alpha-aminoadipyl-cysteinyl-valine (LLD) into isopenicillin N.
Norbert Neuss,Donnis M. Berry,J. Kupka,Arnold L. Demain,S. W. Queener,Dale C. Duckworth,L. L. Huckstep +6 more
TL;DR: Identification of isopenicillin N isolated by HPLC during a biosynthetic cell-free experiment using α-L-aminoadipyl- L-cysteinyl-D-valine (IV) as precursor is permitted.