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Arnon Nagler

Researcher at Sheba Medical Center

Publications -  1435
Citations -  51740

Arnon Nagler is an academic researcher from Sheba Medical Center. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 98, co-authored 1316 publications receiving 44298 citations. Previous affiliations of Arnon Nagler include French Institute of Health and Medical Research & University of Paris.

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Journal Article

Effects of CSFs in preleukemia.

TL;DR: Based on pre-clinical and in vitro studies demonstrating enhanced granulocytic proliferation and differentiation induced by granulocytes-monocyte and granulocyte-colony stimulating factors, these recombinant human hormones have been used to treat cytopenic patients with preleukemia and four of the 18 individuals have subsequently developed AML after 6-16 months.
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The CXCR4 antagonist 4F-benzoyl-TN14003 stimulates the recovery of the bone marrow after transplantation.

TL;DR: The unique ability of the CXCR4 antagonist, T140 to stimulate the production and exit of WBC cells may be used as a novel therapeutic approach to overcome cytopenia associated with treatments for cancer and BM transplantation.
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New developments in bone marrow transplantation.

TL;DR: The data suggest that eradication of the last tumor cell is neither feasible nor necessary for achieving operational cure, and control of minimal residual disease by activation of anticancer effector cells today seems closer than ever.