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Arnon Nagler

Researcher at Sheba Medical Center

Publications -  1435
Citations -  51740

Arnon Nagler is an academic researcher from Sheba Medical Center. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 98, co-authored 1316 publications receiving 44298 citations. Previous affiliations of Arnon Nagler include French Institute of Health and Medical Research & University of Paris.

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Ccr5 deficiency regulates the proliferation and trafficking of natural killer cells under physiological conditions.

TL;DR: Under physiological conditions, the bone marrow, spleen, blood and liver of Ccr5, but not of CCr1-deficient mice, contain reduced numbers of NK cells, suggesting a role for CCr5 in NK cell proliferation and circulation under physiological conditions and a complex role in determining the fate ofNK cells under pathological conditions.
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A Phase I Study of INNO-406 in Patients with Advanced Philadelphia (Ph+) Chromosome-Positive Leukemias Who Are Resistant or Intolerant to Imatinib and Second Generation Tyrosine Kinase Inhibitors.

TL;DR: In this phase I dose finding study, patients with imatinib-resistant or -intolerant Philadelphia (Ph+) chromosome-positive leukemias were eligible for treatment with INNO-406 orally at doses ranging from 30 mg once daily (qd) through 480 mg twice daily (bid).
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Natural Killer Lysis Receptor (NKLR)/NKLR-Ligand Matching as a Novel Approach for Enhancing Anti-Tumor Activity of Allogeneic NK Cells

TL;DR: It is shown that an NKLR-mediated killing directly correlates with the NKLR expression intensity on NK cells, and that common NKLR recognition patterns of tumors would allow implementation of this approach in solid malignancies and potentially in hematological malignancy, either independently or in adjunction to other modalities.