A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
Elena Garreta,Patricia Prado,Megan L. Stanifer,Vanessa Monteil,Andres Marco,Asier Ullate-Agote,Daniel Moya-Rull,Amaia Vilas-Zornoza,Carolina Tarantino,Juan Pablo Romero,Gustav Jonsson,Roger Oria,Alexandra Leopoldi,Astrid Hagelkruys,Maria Gallo,Federico Gonzalez,P. Domingo-Pedrol,Aleix Gavaldà,Carmen Hurtado del Pozo,O. Hasan Ali,Pedro Ventura-Aguiar,Josep M. Campistol,Felipe Prosper,Ali Mirazimi,Steeve Boulant,Josef M. Penninger,Nuria Montserrat +26 more
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TLDR
In this article , the authors established a human kidney organoid model promoting early hallmarks of diabetic kidney disease development and found that diabetic-like kidney organoids exhibited higher viral loads compared with their control counterparts.About:
This article is published in Cell Metabolism.The article was published on 2022-05-01 and is currently open access. It has received 32 citations till now. The article focuses on the topics: Medicine & Organoid.read more
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Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity
Daniel Batlle,Vanessa Monteil,Elena Garreta,Luise Hassler,Jan Wysocki,Vasuretha Chandar,Robert E. Schwartz,Ali Mirazimi,Nuria Montserrat,Michael Bader,Josef M. Penninger +10 more
TL;DR: Yeung et al. as discussed by the authors showed that ACE2 mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.
Journal ArticleDOI
Angiotensin Converting Enzyme 2 - at the Heart of the COVID-19 pandemic
TL;DR: ACE2 is the indispensable entry receptor for SARS and CoV-2 and has become one of the most therapeutically targeted human molecules in biomedicine as mentioned in this paper .
Journal ArticleDOI
Renin‐Angiotensin System Inhibitors in Patients With COVID‐19: A Meta‐Analysis of Randomized Controlled Trials Led by the International Society of Hypertension
Sonali R. Gnanenthiran,Claudio Borghi,Dylan Burger,Bruno Caramelli,Fadi J. Charchar,Julio A. Chirinos,Jordana B. Cohen,Antoine Cremer,Gian Luca Di Tanna,Alexandre Duvignaud,Daniel Freilich,D.H. Frank Gommans,Abraham Edgar Gracia-Ramos,Thomas A. Murray,Facundo Germán Pelorosso,Neil R Poulter,Michael A. Puskarich,Konstantinos D. Rizas,Rodolfo Pedro Rothlin,Markus P. Schlaich,Michael Schreinlecher,Ulrike Muscha Steckelings,Abhinav Sharma,George S. Stergiou,Christopher J. Tignanelli,Maciej Tomaszewski,Thomas Unger,Roland R.J. van Kimmenade,Richard D Wainford,Bryan Williams,Anthony Rodgers,Aletta E. Schutte +31 more
TL;DR: The findings provide strong evidence that RASi can be used safely in patients with COVID‐19 and no difference in all‐cause mortality, a borderline decrease in myocardial infarction, and an increased risk of acute kidney injury are found.
Journal ArticleDOI
Renin‐Angiotensin System Inhibitors in Patients With COVID‐19: A Meta‐Analysis of Randomized Controlled Trials Led by the International Society of Hypertension
TL;DR: In this article , the authors performed a meta-analysis to assess the safety and efficacy of renin-angiotensin system inhibitors (RASi) in adults with COVID-19.
Journal ArticleDOI
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level
Rong Zhu,Daniel Canena,Mateusz Sikora,Miriam Klausberger,Hannah Seferovic,Ahmad Reza Mehdipour,L. Hain,E. Laurent,Vanessa Monteil,Gerald Wirnsberger,Ralph Wieneke,Robert Tampé,Nikolaus F. Kienzl,Lukas Mach,Ali Mirazimi,Yoo Jin Oh,Josef M. Penninger,Gerhard Hummer,Peter Hinterdorfer +18 more
TL;DR: In this article , the Spike trimer acts as a highly dynamic molecular caliper, thereby forming up to three tight bonds through its RBDs with ACE2 expressed on the cell surface.
References
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
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Comprehensive Integration of Single-Cell Data.
Tim Stuart,Andrew Butler,Paul J. Hoffman,Christoph Hafemeister,Efthymia Papalexi,William M. Mauck,Yuhan Hao,Marlon Stoeckius,Peter Smibert,Rahul Satija +9 more
TL;DR: A strategy to "anchor" diverse datasets together, enabling us to integrate single-cell measurements not only across scRNA-seq technologies, but also across different modalities.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.
Alexandra C. Walls,Young-Jun Park,M. Alejandra Tortorici,M. Alejandra Tortorici,Abigail Wall,Andrew T. McGuire,Andrew T. McGuire,David Veesler +7 more
TL;DR: It is demonstrating that cross-neutralizing antibodies targeting conserved S epitopes can be elicited upon vaccination, and it is shown that SARS-CoV-2 S uses ACE2 to enter cells and that the receptor-binding domains of Sars- coV- 2 S and SARS S bind with similar affinities to human ACE2, correlating with the efficient spread of SATS among humans.
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