A
Astrid Haugen-Strano
Researcher at National Institutes of Health
Publications - 10
Citations - 7675
Astrid Haugen-Strano is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Gene mapping. The author has an hindex of 8, co-authored 10 publications receiving 7410 citations.
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Journal ArticleDOI
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
Yoshio Miki,Jeff Swensen,Donna M Shattuck-Eidens,P. Andrew Futreal,Keith D Harshman,Sean V. Tavtigian,Qingyun Liu,Charles Cochran,L. Michelle Bennett,Wei Ding,Russell Bell,Judith Rosenthal,Charles E. Hussey,Thanh Tran,Melody McClure,Cheryl Frye,Tom Hattier,Robert Phelps,Astrid Haugen-Strano,Harold Katcher,Kazuko Yakumo,Zahra Gholami,Daniel Shaffer,Steven Stone,Steven Bayer,Christian Wray,Robert Bogden,Priya Dayananth,John R. Ward,Patricia N. Tonin,Steven A. Narod,Pam K. Bristow,Frank H. Norris,Leah M. Helvering,Paul Morrison,Paul Robert Rosteck,Mei Lai,J. Carl Barrett,Cathryn M. Lewis,Susan L. Neuhausen,Lisa A. Cannon-Albright,David E. Goldgar,Roger W. Wiseman,Alexander Kamb,Mark H. Skolnick +44 more
TL;DR: A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
Journal ArticleDOI
BRCA1 mutations in primary breast and ovarian carcinomas
P. Andrew Futreal,Qingyun Liu,Donna M Shattuck-Eidens,Charles Cochran,Keith D Harshman,Sean V. Tavtigian,L. Michelle Bennett,Astrid Haugen-Strano,Jeff Swensen,Yoshio Miki,Ken Eddington,Melody McClure,Cheryl Frye,Jane Weaver-Feldhaus,Wei Ding,Zahra Gholami,Peter Söderkvist,Lori A. Terry,Suresh C. Jhanwar,Andrew Berchuck,J. Dirk Iglehart,Jeffrey R. Marks,Dennis G. Ballinger,J. Cari Barrett,Mark H. Skolnick,Mark H. Skolnick,Alexander Kamb,Roger W. Wiseman +27 more
TL;DR: Results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.
Journal Article
Homozygous codeletion and differential decreased expression of p15INK4b, p16INK4a-alpha and p16INK4a-beta in mouse lung tumor cells.
Christopher R. Herzog,Erik V. Soloff,McDoniels Al,Tyson Fl,Alvin M. Malkinson,Astrid Haugen-Strano,Roger W. Wiseman,Marshall W. Anderson,Ming You +8 more
TL;DR: Results suggest that both p15INK4b and p16INK4a (alpha and beta) are targets of inactivation in mouse lung tumorigenesis.
Journal ArticleDOI
Isolation of the mouse homologue of BRCA1 and genetic mapping to mouse chromosome 11
Bennett Lm,Astrid Haugen-Strano,Charles Cochran,Brownlee Ha,Frederick T. Fiedorek,Roger W. Wiseman +5 more
TL;DR: The isolation of the murine Brca1 homologue will facilitate the creation of mouse models for germline BRCA1 defects and identify genomic P1 clones that contain most, if not all, of the mouse Brca2 locus.
Journal Article
Characterization of the rat and mouse homologues of the BRCA2 breast cancer susceptibility gene
Kimberly A. McAllister,Astrid Haugen-Strano,Sarah Hagevik,Brownlee Ha,N. Keith Collins,P. Andrew Futreal,L. Michelle Bennett,Roger W. Wiseman +7 more
TL;DR: expression studies demonstrate an 11-12 Kb transcript with rodent tissue-specific patterns of expression consistent with human BRCA2, which will facilitate studies of Brca2 function during normal and neoplastic development.