M
Melody McClure
Researcher at Myriad Genetics
Publications - 9
Citations - 9087
Melody McClure is an academic researcher from Myriad Genetics. The author has contributed to research in topics: Breast cancer & Mutation. The author has an hindex of 8, co-authored 9 publications receiving 8789 citations.
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Journal ArticleDOI
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
Yoshio Miki,Jeff Swensen,Donna M Shattuck-Eidens,P. Andrew Futreal,Keith D Harshman,Sean V. Tavtigian,Qingyun Liu,Charles Cochran,L. Michelle Bennett,Wei Ding,Russell Bell,Judith Rosenthal,Charles E. Hussey,Thanh Tran,Melody McClure,Cheryl Frye,Tom Hattier,Robert Phelps,Astrid Haugen-Strano,Harold Katcher,Kazuko Yakumo,Zahra Gholami,Daniel Shaffer,Steven Stone,Steven Bayer,Christian Wray,Robert Bogden,Priya Dayananth,John R. Ward,Patricia N. Tonin,Steven A. Narod,Pam K. Bristow,Frank H. Norris,Leah M. Helvering,Paul Morrison,Paul Robert Rosteck,Mei Lai,J. Carl Barrett,Cathryn M. Lewis,Susan L. Neuhausen,Lisa A. Cannon-Albright,David E. Goldgar,Roger W. Wiseman,Alexander Kamb,Mark H. Skolnick +44 more
TL;DR: A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
Journal ArticleDOI
BRCA1 mutations in primary breast and ovarian carcinomas
P. Andrew Futreal,Qingyun Liu,Donna M Shattuck-Eidens,Charles Cochran,Keith D Harshman,Sean V. Tavtigian,L. Michelle Bennett,Astrid Haugen-Strano,Jeff Swensen,Yoshio Miki,Ken Eddington,Melody McClure,Cheryl Frye,Jane Weaver-Feldhaus,Wei Ding,Zahra Gholami,Peter Söderkvist,Lori A. Terry,Suresh C. Jhanwar,Andrew Berchuck,J. Dirk Iglehart,Jeffrey R. Marks,Dennis G. Ballinger,J. Cari Barrett,Mark H. Skolnick,Mark H. Skolnick,Alexander Kamb,Roger W. Wiseman +27 more
TL;DR: Results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.
Journal ArticleDOI
Analysis of the p16 gene (CDKN2) as a candidate· for the chromosome 9p melanoma susceptibility locus
Alexander Kamb,Donna M Shattuck-Eidens,Rosalind A. Eeles,Rosalind A. Eeles,Qingyun Liu,Nelleke A. Gruis,Nelleke A. Gruis,Wei Ding,Charles E. Hussey,Thanh Tran,Yoshio Miki,Jane Weaver-Feldhaus,Melody McClure,Joanne F. Aitken,David E. Anderson,Wilma Bergman,Rune R. Frants,David E. Goldgar,Adèle C. Green,Robert MacLennan,Nicholas G. Martin,Laurence Meyer,Laurence Meyer,P. Youl,John J. Zone,Mark H. Skolnick,Mark H. Skolnick,Lisa A. Cannon-Albright +27 more
TL;DR: A locus for familial melanoma, MLM, has been mapped within the same interval on chromosome 9p21 as the gene for a putative cell cycle regulator, p16INK4 (CDKN2) MTS1, suggesting that CDKN2 is a good candidate for MLM.
Journal ArticleDOI
BRCA1 Sequence Analysis in Women at High Risk for Susceptibility Mutations: Risk Factor Analysis and Implications for Genetic Testing
Donna M Shattuck-Eidens,Arnold R. Oliphant,Melody McClure,Celeste McBride,Jamila Gupte,Todd Rubano,Dmitry Pruss,Sean V. Tavtigian,David H. F. Teng,Nils Adey,Mark Staebell,Kathryn Gumpper,Ron Lundstrom,Mark Hulick,Mark Kelly,John Holmen,Beth Lingenfelter,Susan Manley,Frank Fujimura,Michael C. Luce,Brian E. Ward,Lisa A. Cannon-Albright,Linda Steele,Kenneth Offit,Teresa Gilewski,Larry Norton,Karen T. Brown,Charlene Schulz,Heather Hampel,A. Schluger,Elena Giulotto,Wainer Zoli,Alberto Ravaioli,Heli Nevanlinna,Seppo Pyrhonen,Peter T. Rowley,Starlene Loader,Michael P. Osborne,Mary B. Daly,Isidore Tepler,Paul L. Weinstein,Jennifer L. Scalia,Richard Michaelson,Rodney J. Scott,Paolo Radice,Marco A. Pierotti,Judy Garber,Claudine Isaacs,Beth N. Peshkin,Marc E. Lippman,Michael H. Dosik,Maria A. Caligo,Robert M. Greenstein,Robert Pilarski,Barbara L. Weber,Renate Burgemeister,Thomas S. Frank,Mark H. Skolnick,Alun Thomas +58 more
TL;DR: Using logistic regression analysis, this work provides a method for evaluating the probability of a woman's carrying a deleterious BRCA1 mutation for a wide range of cases, which can be an important tool for clinicians as they incorporate genetic susceptibility testing into their medical practice.
Journal ArticleDOI
Low Proportion of BRCA1 and BRCA2 Mutations in Finnish Breast Cancer Families: Evidence for Additional Susceptibility Genes
Paula Vehmanen,Lori Friedman,Hannaleena Eerola,Melody McClure,Brian E. Ward,Laura Sarantaus,Tommi Kainu,Kirsi Syrjäkoski,Seppo Pyrhönen,Olli-P. Kallioniemi,T Muhonen,Michael C. Luce,Thomas S. Frank,Heli Nevanlinna +13 more
TL;DR: Data indicate that additional breast and breast-ovarian cancer susceptibility genes are likely to be important in Finland, despite expectations based on Finnish population history and strong founder effects in several monogenic diseases in Finland.