Athanassios Karageorgos

TL;DR: In this paper, the authors found that severe respiratory failure (SRF) in COVID-19 patients is driven by a unique pattern of immune dysfunction, characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation.

TL;DR: Data show that BCG vaccination is safe and can protect the elderly against infections, and larger studies are needed to assess protection against respiratory infections, including COVID-19.

TL;DR: This case series presents five patients, ages 27 to 44 years, who came to the Orthopaedic Department outpatient clinic for evaluation of pain in the humerus, clavicle, sacroiliac joints, and/or distal radius, and were diagnosed with SAPHO syndrome, and treatment with antibiotics and non steroid anti-inflammatory drugs was remarkably effective.

TL;DR: In this paper, an open-label non-randomized trial in 90 patients with COVID-19 of moderate severity was conducted between May and October 2020, where the primary endpoint was defined at the end of treatment (EOT) as no need for hospital re-admission and no progression into lower respiratory tract infection (LRTI) for patients with upper respiratory tract infections and as at least 50% decrease of the respiratory symptoms score without progression into severe respiratory failure (SRF) for those with LRTI.

TL;DR: The studied optical biosensor seems valuable for the discrimination of infection severity and diagnosed severe COVID-19 with 83.3% sensitivity and 87.5% negative predictive value.