A
Axel Rosendahl Huber
Publications - 9
Citations - 712
Axel Rosendahl Huber is an academic researcher. The author has contributed to research in topics: Progenitor cell & Mutation. The author has an hindex of 3, co-authored 6 publications receiving 342 citations.
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Journal ArticleDOI
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.
Cayetano Pleguezuelos-Manzano,Jens Puschhof,Axel Rosendahl Huber,Arne Van Hoeck,Henry M. Wood,Jason Nomburg,Jason Nomburg,Carino Gurjao,Carino Gurjao,Freek Manders,Guillaume Dalmasso,Paul B. Stege,Fernanda L. Paganelli,Maarten H. Geurts,Joep Beumer,Tomohiro Mizutani,Yi Miao,Reinier van der Linden,Stefan van der Elst,K. Christopher Garcia,Janetta Top,Rob J. L. Willems,Marios Giannakis,Marios Giannakis,Richard Bonnet,Phil Quirke,Matthew Meyerson,Edwin Cuppen,Ruben van Boxtel,Hans Clevers +29 more
TL;DR: A distinct mutational signature in colorectal cancer is described and it is implied that the underlying mutational process results directly from past exposure to bacteria carrying the colibactin-producing pks pathogenicity island.
Journal ArticleDOI
Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis.
Fernando G. Osorio,Fernando G. Osorio,Axel Rosendahl Huber,Rurika Oka,Mark Verheul,Sachin Patel,Sachin Patel,Karlijn Hasaart,Lisanne de la Fonteijne,Ignacio Varela,Fernando D. Camargo,Fernando D. Camargo,Ruben van Boxtel +12 more
TL;DR: It is found that mutations accumulate gradually during life with approximately 14 base substitutions per year, and a developmental lineage tree of human hematopoiesis is constructed, revealing a polyclonal architecture and providing evidence that developmental clones exhibit multipotency.
Journal ArticleDOI
Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients
Jurrian K. de Kanter,Flavia Peci,E.J.M. Bertrums,Axel Rosendahl Huber,Anaïs van Leeuwen,Markus J van Roosmalen,Freek Manders,Mark Verheul,Rurika Oka,Arianne M. Brandsma,Marc Bierings,Mirjam E. Belderbos,Ruben van Boxtel +12 more
TL;DR: In this paper, the mutation burden of hematopoietic stem and progenitor cells (HSPCs) of human HSCT recipients and their donors using whole-genome sequencing was characterized.
Journal ArticleDOI
Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms
Eline J M Bertrums,Axel Rosendahl Huber,Jurrian K. de Kanter,Arianne M. Brandsma,A. V. van Leeuwen,Mark Verheul,Marry M. van den Heuvel-Eibrink,Rurika Oka,Markus J. van Roosmalen,Hester A. de Groot-Kruseman,C. Michel Zwaan,Bianca F. Goemans,Ruben van Boxtel +12 more
TL;DR: In this article , the mutation burden of normal blood cells in childhood cancer survivors by direct treatment-induced mutagenesis and enhanced activity of processes that are also present during healthy aging was investigated.
Journal ArticleDOI
Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene
Jawara Allen,Axel Rosendahl Huber,Cayetano Pleguezuelos-Manzano,Jens Puschhof,Shaoguang Wu,Xinqun Wu,Charelle Boot,Aurelia Saftien,Heather M. O'Hagan,Ruben van Boxtel,Hans Clevers,Cynthia L. Sears +11 more
TL;DR: Investigating the impact of ETBF-induced genetic changes on tumor formation informs how this procarcinogenic bacterium may promote tumor formation in individuals with inherited predispositions to CRC, such as Lynch syndrome or familial adenomatous polyposis