Aysegul Guvenek

TL;DR: It is suggested that selection strength is an important parameter contributing to the complexity of antibiotic resistance problem and use of high doses of antibiotics to clear infections has the potential to promote increase of cross-resistance in clinics.

TL;DR: This work comprehensively quantify the distribution of fitness effects of mutations, a key determinant of evolutionary dynamics, in the presence of eight antibiotics representing the main modes of action and identified novel quantitative characteristics of the evolutionary landscape that provide the conceptual foundation for predicting the dynamics of drug resistance evolution.

TL;DR: In this article , the authors identify a variant (rs190509934, minor allele frequency 0.2-2%) that downregulates ACE2 expression by 37% and reduces the risk of SARS-CoV-2 infection by 40% (odds ratio = 0.60, P = 4.5 × 10 − 13 ).

TL;DR: Detailed analysis of APA following induction of long-term potentiation of mouse hippocampal CA3-CA1 synapses reveals that activity-dependent APA provides an important layer of gene regulation during learning and memory.

TL;DR: The data delineate APA profiles in different brain cells and indicate that APA regulation in neurogenesis is largely an augmented process taking place in other types of cell differentiation, including myogenesis and differentiation of embryonic stem cells into neurons.