D
Danny S. Park
Researcher at University of California, San Francisco
Publications - 49
Citations - 2171
Danny S. Park is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 15, co-authored 43 publications receiving 1394 citations. Previous affiliations of Danny S. Park include Harvard University & Steward Health Care System.
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Journal ArticleDOI
Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay
Ryan Tewhey,Ryan Tewhey,Dylan Kotliar,Dylan Kotliar,Danny S. Park,Brandon Liu,Sarah M. Winnicki,Steven K. Reilly,Steven K. Reilly,Kristian G. Andersen,Kristian G. Andersen,Tarjei S. Mikkelsen,Eric S. Lander,Stephen F. Schaffner,Pardis C. Sabeti,Pardis C. Sabeti +15 more
TL;DR: The massively parallel reporter assay (MPRA) is adapted to identify variants that directly modulate gene expression, using it to identify 842 variants showing differential expression between alleles, including 53 well-annotated variants associated with diseases and traits.
Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay
Danny S. Park,Brandon Liu,Sarah M. Winnicki,Steven K. Reilly,Kristian G. Andersen,Ryan Tewhey,Dylan Kotliar,Kristian Andersen,Tarjei S. Mikkelsen,Eric S. Lander,Stephen F. Schaffner,Pardis C. Sabeti +11 more
TL;DR: The massively parallel reporter assay (MPRA) is adapted to identify variants that directly modulate gene expression, and 842 variants showing differential expression between alleles are identified, including 53 well-annotated variants associated with diseases and traits.
Journal ArticleDOI
CloudMap: A Cloud-Based Pipeline for Analysis of Mutant Genome Sequences
TL;DR: A novel, easily accessible and cloud-based pipeline, called CloudMap, which greatly simplifies the analysis of mutant genome sequences and describes the application of a novel mapping/WGS method that does not rely on a defined polymorphic mapping strain, and is integrated into CloudMap.
Journal ArticleDOI
Campylobacter jejuni Type VI Secretion System: Roles in Adaptation to Deoxycholic Acid, Host Cell Adherence, Invasion, and In Vivo Colonization
Kvin Lertpiriyapong,Eric R. Gamazon,Yan Feng,Danny S. Park,Jassia Pang,Georgina Botka,Michelle E. Graffam,Zhongming Ge,James G. Fox +8 more
TL;DR: Evidence is provided that the enteric pathogen, Campylobacter jejuni, possesses a functional T6SS and that the secretion system exerts pleiotropic effects on two crucial processes – survival in a bile salt, deoxycholic acid (DCA), and host cell adherence and invasion.
Posted ContentDOI
A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa.
Eduan Wilkinson,Eduan Wilkinson,Marta Giovanetti,Marta Giovanetti,Houriiyah Tegally,James Emmanuel San,Richard J Lessells,Diego F. Cuadros,Darren P. Martin,David A. Rasmussen,Abdel-Rahman N. Zekri,Abdoul K. Sangare,Abdoul-Salam Ouédraogo,Abdul Karim Sesay,Abechi Priscilla,Adedotun-Sulaiman Kemi,Adewunmi M. Olubusuyi,Adeyemi O. O. Oluwapelumi,Adnene Hammami,Adrienne A. Amuri,Ahmad Sayed,Ahmed E Ogwell Ouma,Aida Elargoubi,Nnennaya A. Ajayi,Ajogbasile F. Victoria,Akano Kazeem,Akpede George,Alexander J. Trotter,Ali Ahmed Yahaya,Alpha Kabinet Keita,Amadou Diallo,Amadou Koné,Amal Souissi,Amel Chtourou,Ana Victoria Gutierrez,Andrew J. Page,Anika Vinze,Arash Iranzadeh,Arnold W. Lambisia,Arshad Ismail,Audu Rosemary,Augustina Sylverken,Ayoade Femi,Azeddine Ibrahimi,Baba Marycelin,Bamidele Soji Oderinde,Bankole Bolajoko,Beatrice Dhaala,Belinda Louise Herring,Berthe-Marie Njanpop-Lafourcade,Bronwyn Kleinhans,Bronwyn McInnis,Bryan Fulbert Nkengfack Tegomoh,Cara E. Brook,Cara E. Brook,Catherine Pratt,Cathrine Scheepers,Cathrine Scheepers,Chantal Akoua-Koffi,Charles N. Agoti,Charles N. Agoti,Christophe Peyrefitte,Claudia Daubenberger,Collins M. Morang’a,D. James Nokes,D. James Nokes,Daniel G. Amoako,Daniel Lule Bugembe,Danny S. Park,David Baker,Deelan Doolabh,Deogratius Ssemwanga,Deogratius Ssemwanga,Derek Tshiabuila,Diarra Bassirou,Dominic S. Y. Amuzu,Dominique Goedhals,Donwilliams O. Omuoyo,Dorcas Maruapula,Ebenezer Foster-Nyarko,Eddy Kinganda Lusamaki,Edgar Simulundu,Edidah M. Ong'era,Edith N. Ngabana,Edwin Shumba,Elmostafa El Fahime,Emmanuel Lokilo,Enatha Mukantwari,Eromon Philomena,Essia Belarbi,Etienne Simon-Loriere,Etile Anoh,Fabian H. Leendertz,Faida Ajili,Fakayode O. Enoch,Fares Wasfi,Fatma Abdelmoula,Fausta Shakiwa Mosha,Faustinos T. Takawira,Fawzi Derrar,Feriel Bouzid,Folarin Onikepe,Fowotade Adeola,Francisca M. Muyembe,Frank Tanser,Frank Tanser,Frank Tanser,Fred A. Dratibi,Gabriel K. Mbunsu,Gaetan Thilliez,Gemma L. Kay,George Githinji,George Githinji,Gert U. van Zyl,Gert U. van Zyl,Gordon A. Awandare,Grit Schubert,Gugu Maphalala,Hafaliana Christian Ranaivoson,Hajar Lemriss,Happi Anise,Haruka Abe,Hela Karray,Hellen Nansumba,Hesham A. Elgahzaly,Hlanai Gumbo,Ibtihel Smeti,Ikhlas Ben Ayed,Ikponmwosa Odia,Ilhem Boutiba-Ben Boubaker,Imed Gaaloul,Inbal Gazy,Innocent Mudau,Isaac Ssewanyana,Iyaloo Konstantinus,Jean B. Lekana-Douk,Jean-Claude C Makangara,Jean-Jacques Muyembe Tamfum,Jean-Michel Heraud,Jeffrey G. Shaffer,Jennifer Giandhari,Jingjing Li,Jiro Yasuda,Joana Q. Mends,Jocelyn Kiconco,John M. Morobe,John O. Gyapong,Johnson C. Okolie,John Kayiwa,Johnathan A. Edwards,Johnathan A. Edwards,Jones Gyamfi,Jouali Farah,Joweria Nakaseegu,Joyce M. Ngoi,Joyce Namulondo,Julia C. Andeko,Julius J. Lutwama,Justin O'Grady,Katherine J. Siddle,Kayode T. Adeyemi,Kefentse A. Tumedi,K Said,Kim Hae-Young,Kwabena O. Duedu,Lahcen Belyamani,Lamia Fki-Berrajah,Lavanya Singh,Leonardo de Oliveira Martins,Lynn Tyers,Magalutcheemee Ramuth,Maha Mastouri,Mahjoub Aouni,Mahmoud el Hefnawi,Maitshwarelo I. Matsheka,Malebogo Kebabonye,Mamadou Diop,Manel Turki,Mariétou Faye Paye,Martin M. Nyaga,Mathabo Mareka,Matoke-Muhia Damaris,Maureen W. Mburu,Maximillian Mpina,Maximillian Mpina,Mba Nwando,Michael Owusu,Michael R. Wiley,Mirabeau T. Youtchou,Mitoha O. Ayekaba,Mohamed Abouelhoda,Mohamed G. Seadawy,Mohamed K. Khalifa,Mooko Sekhele,Mouna Ouadghiri,Moussa Moïse Diagne,Mulenga Mwenda,Mushal Allam,My V. T. Phan,Nabil Abid,Nabil Abid,Nadia Touil,Nadine Rujeni,Najla Kharrat,Nalia Ismael,Ndongo Dia,Nedio Mabunda,Nei-yuan Hsiao,Nei-yuan Hsiao,Nelson B. Silochi,Ngoy Nsenga,Nicksy Gumede,Nicola Mulder,Nnaemeka Ndodo,Norosoa Harline Razanajatovo,Nosamiefan Iguosadolo,Oguzie Judith,Ojide Chiedozie Kingsley,Okogbenin Sylvanus,Okokhere Peter,Oladiji Femi,Olawoye Idowu,Olumade Testimony,Omoruyi E. Chukwuma,Onwe E. Ogah,Chika K. Onwuamah,Oshomah Cyril,Ousmane Faye,Oyewale Tomori,Pascale Ondoa,Patrice Combe,Patrick Semanda,Paul E. Oluniyi,Paulo Arnaldo,Peter K. Quashie,Philippe Dussart,Phillip Armand Bester,Placide Mbala,Reuben Ayivor-Djanie,Richard Njouom,Richard Phillips,Richmond Gorman,Robert A. Kingsley,Rosina A. A. Carr,Saâd El Kabbaj,Saba Gargouri,Saber Masmoudi,Safietou Sankhe,Salako B. Lawal,Samar K. Kassim,Sameh Trabelsi,Samar Metha,Sami Kammoun,Sanaâ Lemriss,Sara H.A. Agwa,Sébastien Calvignac-Spencer,Stephen F. Schaffner,Seydou Doumbia,Sheila M. Mandanda,Sherihane Aryeetey,Shymaa S. Ahmed,Siham Elhamoumi,Soa-Fy Andriamandimby,Sobajo Tope,Sonia Lekana-Douki,Sophie J Prosolek,Soumeya Ouangraoua,Steve A. Mundeke,Steven Rudder,Sumir Panji,Sureshnee Pillay,Susan Engelbrecht,Susan Engelbrecht,Susan Nabadda,Sylvie Behillil,Sylvie L. Budiaki,Sylvie van der Werf,Tapfumanei Mashe,Tarik Aanniz,Thabo Mohale,Thanh Le-Viet,Tobias Schindler,Ugochukwu J. Anyaneji,Ugwu Chinedu,Upasana Ramphal,Upasana Ramphal,Uwanibe Jessica,U George,Vagner Fonseca,Vagner Fonseca,Vincent Enouf,Vivianne Gorova,Wael H. Roshdy,William Ampofo,Wolfgang Preiser,Wolfgang Preiser,Wonderful T. Choga,Wonderful T. Choga,Yaw Bediako,Yeshnee Naidoo,Yvan Butera,Zaydah R. de Laurent,Amadou A. Sall,Ahmed Rebai,Anne von Gottberg,Anne von Gottberg,Bourema Kouriba,Carolyn Williamson,Carolyn Williamson,Carolyn Williamson,Daniel J. Bridges,Ihekweazu Chikwe,Jinal N. Bhiman,Jinal N. Bhiman,Madisa Mine,Matthew Cotten,Matthew Cotten,Sikhulile Moyo,Simani Gaseitsiwe,Ngonda Saasa,Pardis C. Sabeti,Pontiano Kaleebu,Yenew K. Tebeje,Sofonias K. Tessema,Christian T. Happi,John N. Nkengasong,Tulio de Oliveira +326 more
TL;DR: In this paper, the authors describe the genomic epidemiology using a dataset of 8746 genomes from 33 African countries and two overseas territories and show that the epidemics in most countries were initiated by importations predominantly from Europe, which diminished following the early introduction of international travel restrictions.