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Baoen Chen
Researcher at Harvard University
Publications - 19
Citations - 874
Baoen Chen is an academic researcher from Harvard University. The author has contributed to research in topics: Palmitoylation & Protein palmitoylation. The author has an hindex of 9, co-authored 16 publications receiving 584 citations. Previous affiliations of Baoen Chen include Chinese Academy of Sciences.
Papers
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Journal ArticleDOI
Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor
Baoen Chen,Fei Ye,Lu Yu,Guifang Jia,Xiaotian Huang,X.-B. Zhang,Shuying Peng,Kai Chen,Meining Wang,Shouze Gong,Ruihan Zhang,Jinya Yin,Haiyan Li,Yiming Yang,Hong Liu,Jiwen Zhang,Hai-Yan Zhang,Ao Zhang,Hualiang Jiang,Cheng Luo,Cai-Guang Yang,Cai-Guang Yang +21 more
TL;DR: The first identification of several small-molecule inhibitors of human FTO demethylase is reported, including the most potent compound, the natural product rhein, which is neither a structural mimic of 2-oxoglutarate nor a chelator of metal ion.
Journal ArticleDOI
Protein Lipidation in Cell Signaling and Diseases: Function, Regulation, and Therapeutic Opportunities.
TL;DR: Recent progress is highlighted in the understanding of protein lipidation, in particular, S-palmitoylation and lysine fatty acylation, and the importance of these modifications for protein regulation, cell signaling, and diseases is described.
Journal ArticleDOI
Palmitoylation-dependent activation of MC1R prevents melanomagenesis.
Shuyang Chen,Bo Zhu,Chengqian Yin,Wei Liu,Changpeng Han,Baoen Chen,Tongzheng Liu,Xin Li,Xiang Chen,Chunying Li,Limin Hu,Jun Zhou,Zhi-Xiang Xu,Xiumei Gao,Xu Wu,Colin R. Goding,Rutao Cui +16 more
TL;DR: It is shown that pharmacological activation of palmitoylation rescues the defects of Mc1r RHC variants and prevents melanomagenesis, highlighting a central role for MC1R palmitoyslation in pigmentation and protection against melanoma.
Journal ArticleDOI
ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity
Baoen Chen,Baohui Zheng,Michael DeRan,Gopala K. Jarugumilli,Jianjun Fu,Yang Sui Brooks,Xu Wu +6 more
TL;DR: Using chemical reporters, it is shown that SCRIB localization is regulated by S-palmitoylation at conserved cysteine residues, and that ZDHHC7 is the major palmitoyl acyltransferase regulatingSCRIB.
Journal ArticleDOI
Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer
Zhongqiang Guo,Zhongqiang Guo,Zhongqiang Guo,Tong Zheng,Baoen Chen,Cheng Luo,Sisheng Ouyang,Shouzhe Gong,Jiafei Li,Liu-Liang Mao,Fulin Lian,Yong Yang,Yue Huang,Li Li,Jing Lu,Bidong Zhang,Luming Zhou,Hong Ding,Zhiwei Gao,Liqun Zhou,Guoqiang Li,Ran Zhou,Ke Chen,Jingqiu Liu,Yi Wen,Likun Gong,Yuwen Ke,Shang-Dong Yang,Xiao-Bo Qiu,Naixia Zhang,Jin Ren,Dafang Zhong,Cai-Guang Yang,Jiang Liu,Hualiang Jiang +34 more
TL;DR: It is shown that a structure-based design and subsequent hit optimization yield small molecules that can inhibit the SPOP-substrate protein interaction and can suppress oncogenic SPop-signaling pathways.