J
Jiwen Zhang
Researcher at Chinese Academy of Sciences
Publications - 156
Citations - 3062
Jiwen Zhang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 23, co-authored 110 publications receiving 1874 citations. Previous affiliations of Jiwen Zhang include Peking University & Shenyang Pharmaceutical University.
Papers
More filters
Journal ArticleDOI
Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor
Baoen Chen,Fei Ye,Lu Yu,Guifang Jia,Xiaotian Huang,X.-B. Zhang,Shuying Peng,Kai Chen,Meining Wang,Shouze Gong,Ruihan Zhang,Jinya Yin,Haiyan Li,Yiming Yang,Hong Liu,Jiwen Zhang,Hai-Yan Zhang,Ao Zhang,Hualiang Jiang,Cheng Luo,Cai-Guang Yang,Cai-Guang Yang +21 more
TL;DR: The first identification of several small-molecule inhibitors of human FTO demethylase is reported, including the most potent compound, the natural product rhein, which is neither a structural mimic of 2-oxoglutarate nor a chelator of metal ion.
Journal ArticleDOI
Composite CD-MOF nanocrystals-containing microspheres for sustained drug delivery
Haiyan Li,Haiyan Li,Nana Lv,Nana Lv,Xue Li,Xue Li,Botao Liu,Botao Liu,Jing Feng,Xiaohong Ren,Tao Guo,Dawei Chen,J. Fraser Stoddart,Ruxandra Gref,Jiwen Zhang,Jiwen Zhang +15 more
TL;DR: These composite microspheres, composed of CD-MOF nanocrystals embedded in a biocompatible polymer (PAA) matrix, constitute an efficient and pharmaceutically acceptable MOF-based carrier for sustained drug release.
Journal ArticleDOI
Metal-organic frameworks for advanced drug delivery
Siyu He,Li Wu,Xue Li,Hongyu Sun,Ting Xiong,Ting Xiong,Jie Liu,Chengxi Huang,Huipeng Xu,Huimin Sun,Weidong Chen,Ruxandra Gref,Jiwen Zhang +12 more
TL;DR: An overall review and perspectives of MOFs-based drug delivery systems (DDSs), starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands, followed by the drug loading strategies, applications, biopharmaceutics and quality control.
Journal ArticleDOI
Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal-Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application.
Shailendra Shakya,Yaping He,Xiaohong Ren,Tao Guo,Abi Maharjan,Ting Luo,Ting Luo,Tingting Wang,Tingting Wang,Ramesh Dhakhwa,Balmukunda Regmi,Haiyan Li,Ruxandra Gref,Jiwen Zhang +13 more
TL;DR: A template-guided synthesis of ultrafine Ag NPs of around 2 nm using water-soluble and biocompatible γ-cyclodextrin metal-organic frameworks (CD-MOFs) is reported, achieving dual functions of reduced particle size and enhanced stability.
Journal ArticleDOI
Microwave-Assisted Rapid Synthesis of γ-Cyclodextrin Metal–Organic Frameworks for Size Control and Efficient Drug Loading
Botao Liu,Botao Liu,Yaping He,Liping Han,Vikramjeet Singh,Xiaonan Xu,Tao Guo,Fanyue Meng,Xu Xu,Peter York,Zhaoxin Liu,Jiwen Zhang,Jiwen Zhang +12 more
TL;DR: The micron and nanometer-sized γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) were successfully synthesized using the microwave technique for the first time for rapid and facile synthesis as discussed by the authors.