Shuying Peng

TL;DR: The first identification of several small-molecule inhibitors of human FTO demethylase is reported, including the most potent compound, the natural product rhein, which is neither a structural mimic of 2-oxoglutarate nor a chelator of metal ion.

TL;DR: An extensive crosstalk between O-GlcNAcylations and phosphorylations of Akt was revealed and O- GlcNAcylation was demonstrated as a new regulatory modification for Akt signaling.

TL;DR: The results showed that SARS_NP existed in vitro as oligomer, more probably dimer, as the basic functional unit, and this protein shows its maximum conformational stability near pH 9.0, and it seems that its oligomer dissociation and protein unfolding occur simultaneously.

TL;DR: Belonging to one of the major proteins associated with SARS_CoV, SARS 3C-like protease (SARS_3CLpro) functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents.

TL;DR: The cloning and enzymatic characterization of FabZ from H. pylori strain SS1 were reported, and the gene sequence of HpfabZ was deposited in the GenBank database, and it was suggested that HpFabZ exists as hexamer in native state.