B
Baohong Zhao
Researcher at Cornell University
Publications - 105
Citations - 3555
Baohong Zhao is an academic researcher from Cornell University. The author has contributed to research in topics: Osteoclast & Bone resorption. The author has an hindex of 28, co-authored 88 publications receiving 2819 citations. Previous affiliations of Baohong Zhao include Peking University & Showa University.
Papers
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Journal ArticleDOI
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
Haixia Xu,Jimmy Zhu,Sinead M. Smith,Julia Foldi,Baohong Zhao,Allen Y. Chung,Hasina H. Outtz,Jan Kitajewski,Chao Shi,Chao Shi,Silvio Weber,Paul Saftig,Yueming Li,Keiko Ozato,Carl P. Blobel,Lionel B. Ivashkiv,Lionel B. Ivashkiv,Xiaoyu Hu,Xiaoyu Hu +18 more
TL;DR: A signaling network in which signaling via Notch–RBP-J and TLRs is integrated at the level of synthesis of IRF8 protein is defined and a mechanism by which heterologous signaling pathways can regulate the TLR-induced inflammatory polarization of macrophages is identified.
Journal ArticleDOI
Bone formation enhanced by implanted octacalcium phosphate involving conversion into Ca-deficient hydroxyapatite
Osamu Suzuki,Shinji Kamakura,Takenobu Katagiri,Masanori Nakamura,Baohong Zhao,Yoshitomo Honda,Ryutaro Kamijo +6 more
TL;DR: Results suggest that OCP supports appositional bone formation and OCP-apatite conversion may be involved in this stimulatory capacity of OCP.
Journal ArticleDOI
Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2
Baohong Zhao,Takenobu Katagiri,Hiromitsu Toyoda,Takatora Takada,Takako Yanai,Toru Fukuda,Ung-il Chung,Tatsuya Koike,Kunio Takaoka,Ryutaro Kamijo +9 more
TL;DR: It is indicated that heparin enhances BMP-induced osteoblast differentiation in vitro and in vivo by protecting BMPs from degradation and inhibition by BMP antagonists.
Journal ArticleDOI
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis
Baohong Zhao,Masamichi Takami,Atsushi Yamada,Xiaogu Wang,Takako Koga,Xiaoyu Hu,Xiaoyu Hu,Tomohiko Tamura,Keiko Ozato,Yongwon Choi,Lionel B. Ivashkiv,Lionel B. Ivashkiv,Hiroshi Takayanagi,Ryutaro Kamijo +13 more
TL;DR: It is reported that interferon regulatory factor-8 (IRF-8), a transcription factor expressed in immune cells, is a key regulatory molecule for osteoclastogenesis and suggested a model where downregulation of inhibitory factors such as IRf-8 contributes to RANKL-mediated osteoclineogenesis.
Journal ArticleDOI
Targeting skeletal endothelium to ameliorate bone loss
Ren Xu,Alisha R. Yallowitz,An Qin,Zhuhao Wu,Dong Yeon Shin,Jung-Min Kim,Shawon Debnath,Gang Ji,Gang Ji,Mathias P.G. Bostrom,Xu Yang,Chao Zhang,Han Dong,Han Dong,Pouneh Kermani,Sarfaraz Lalani,Na Li,Yifang Liu,Michael G. Poulos,Amanda Wach,Yi Zhang,Kazuki Inoue,Kazuki Inoue,Annarita Di Lorenzo,Baohong Zhao,Baohong Zhao,Jason M. Butler,Jae-Hyuck Shim,Laurie H. Glimcher,Laurie H. Glimcher,Matthew B. Greenblatt +30 more
TL;DR: Recombinant SLIT3 represents a new mechanistic approach to treating osteoporosis by increasing skeletal CD31hiEMCNhi vascular endothelium and drugs that target the SLit3 pathway may represent a new approach for vascular-targeted osteoanabolic therapy to treat bone loss.