Michael G. Poulos

TL;DR: It is found that mammalian bone marrow stem cell maintenance and leukocyte trafficking are regulated by distinct blood vessel types with different permeability properties, and exposure to blood plasma increases bone marrow HSPC ROS levels, augmenting their migration and differentiation, while compromising their long-term repopulation and survival.

TL;DR: It is shown that clusters of transcription factors, angiocrine growth factors, adhesion molecules, and chemokines are expressed in unique combinations by ECs of each organ.

TL;DR: It is demonstrated that expression of the angiocrine factor Jagged-1, supplied by the BM vascular niche, regulates homeostatic and regenerative hematopoiesis through a Notch-dependent mechanism.

TL;DR: A tractable approach for fully reprogramming adult mouse endothelial cells to haematopoietic stem cells (rEC-HSCs) through transient expression of the transcription-factor-encoding genes Fosb, Gfi1, Runx1, and Spi1 and vascular-niche-derived angiocrine factors is demonstrated.

TL;DR: Recombinant SLIT3 represents a new mechanistic approach to treating osteoporosis by increasing skeletal CD31hiEMCNhi vascular endothelium and drugs that target the SLit3 pathway may represent a new approach for vascular-targeted osteoanabolic therapy to treat bone loss.