S
Silvio Weber
Researcher at Dresden University of Technology
Publications - 27
Citations - 1533
Silvio Weber is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: ADAM10 & Protein phosphatase 1. The author has an hindex of 14, co-authored 25 publications receiving 1281 citations. Previous affiliations of Silvio Weber include University of Göttingen & University of Kiel.
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Journal ArticleDOI
The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex
Ellen Jorissen,Johannes Prox,Christian Bernreuther,Silvio Weber,Ralf Schwanbeck,Lutgarde Serneels,An Snellinx,Kathleen Craessaerts,Amantha Thathiah,Ina Tesseur,Udo Bartsch,Gisela Weskamp,Carl P. Blobel,Markus Glatzel,Bart De Strooper,Paul Saftig +15 more
TL;DR: This study reveals that ADAM10 plays a central role in the developing brain by controlling mainly Notch-dependent pathways but likely also by reducing surface shedding of other neuronal membrane proteins including APP.
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Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
Haixia Xu,Jimmy Zhu,Sinead M. Smith,Julia Foldi,Baohong Zhao,Allen Y. Chung,Hasina H. Outtz,Jan Kitajewski,Chao Shi,Chao Shi,Silvio Weber,Paul Saftig,Yueming Li,Keiko Ozato,Carl P. Blobel,Lionel B. Ivashkiv,Lionel B. Ivashkiv,Xiaoyu Hu,Xiaoyu Hu +18 more
TL;DR: A signaling network in which signaling via Notch–RBP-J and TLRs is integrated at the level of synthesis of IRF8 protein is defined and a mechanism by which heterologous signaling pathways can regulate the TLR-induced inflammatory polarization of macrophages is identified.
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Ectodomain shedding and ADAMs in development
Silvio Weber,Paul Saftig +1 more
TL;DR: This Review summarizes the fascinating roles of ADAMs in embryonic and adult tissue development in both vertebrates and invertebrates.
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The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling
Silvio Weber,Michaela T. Niessen,Johannes Prox,Renate Lüllmann-Rauch,Annika Schmitz,Ralf Schwanbeck,Carl P. Blobel,Ellen Jorissen,Bart De Strooper,Carien M. Niessen,Paul Saftig +10 more
TL;DR: The disintegrin and metalloproteinase Adam10 has been implicated in the regulation of key signaling pathways that determine skin morphogenesis and homeostasis, and selectively disrupted Adam10 during skin morphology and in adult skin this article.
Journal ArticleDOI
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10
Johannes Prox,Michael Willenbrock,Silvio Weber,Tobias Lehmann,Dirk Schmidt-Arras,Ralf Schwanbeck,Paul Saftig,Michael Schwake +7 more
TL;DR: The data show that TSPAN15 is a central modulator of ADAM10-mediated ectodomain shedding and Therapeutic manipulation of its expression levels may be an additional approach to specifically regulate the activity of the amyloid precursor protein alpha-secretase ADAM 10.