B
Bassel E. Sawaya
Researcher at Temple University
Publications - 92
Citations - 6100
Bassel E. Sawaya is an academic researcher from Temple University. The author has contributed to research in topics: Transcription (biology) & Transcription factor. The author has an hindex of 32, co-authored 85 publications receiving 5300 citations. Previous affiliations of Bassel E. Sawaya include Allegheny University of the Health Sciences & Drexel University.
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Journal ArticleDOI
Monocyte chemoattractant protein-1 (MCP-1): an overview.
TL;DR: This review will discuss the biological processes and the structure and function of CCL2, one of the key chemokines that regulate migration and infiltration of monocytes/macrophages.
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HIV-1 associated dementia: symptoms and causes
TL;DR: HIV-associated cognitive impairment correlates with the increased presence in the CNS of activated, though not necessarily HIV-1-infected, microglia and CNS macrophages, suggesting that indirect mechanisms of neuronal injury and loss/death occur in HIV/AIDS as a basis for dementia since neurons are not themselves productively infected by HIV- 1.
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Cooperative Interaction between HIV-1 Regulatory Proteins Tat and Vpr Modulates Transcription of the Viral Genome
TL;DR: By structural and functional interaction with Tat, a potent viral regulatory protein, Vpr synergistically enhances the transcriptional activity of the HIV-1 LTR and suggests a working model on the cooperative interaction of Vpr with viral and cellular proteins and its involvement in control of viral gene transcription and replication.
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p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1.
Thomas Cherrier,S Suzanne,L Redel,Miriam Calao,Céline Marban,Boubekeur Samah,Ruma Mukerjee,Christian Schwartz,Gabriel Gras,Bassel E. Sawaya,Steven L. Zeichner,Dominique Aunis,C Van Lint,Olivier Rohr +13 more
TL;DR: The results suggest that CTIP2 is a constitutive p 21 gene suppressor that cooperates with SUV39H1 and histone methylation to silence the p21 gene transcription.
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Activation of the Oxidative Stress Pathway by HIV-1 Vpr Leads to Induction of Hypoxia-inducible Factor 1α Expression
Satish L. Deshmane,Ruma Mukerjee,Shongshan Fan,Luis Del Valle,Carine Michiels,Thersa Sweet,Inna Rom,Kamel Khalili,Jay Rappaport,Shohreh Amini,Bassel E. Sawaya +10 more
TL;DR: The results point to the activation of hypoxia-inducible factor 1 (HIF-1) upon HIV-1 infection and its elevation in brain cells of AIDS patients with dementia and that, by inducing oxidative stress via activation of Hif-1, Vpr can induce HIV- 1 gene expression and dysregulate multiple host cellular pathways.