Monocyte chemoattractant protein-1 (MCP-1): an overview.
TLDR
This review will discuss the biological processes and the structure and function of CCL2, one of the key chemokines that regulate migration and infiltration of monocytes/macrophages.Abstract:
Chemokines constitute a family of chemoattractant cytokines and are subdivided into four families on the basis of the number and spacing of the conserved cysteine residues in the N-terminus of the protein. Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled receptors. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its receptor CCR2 have been demonstrated to be induced and involved in various diseases. Migration of monocytes from the blood stream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as in response to inflammation. This review will discuss these biological processes and the structure and function of CCL2.read more
Citations
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References
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Decreased lesion formation in CCR2 −/− mice reveals a role for chemokines in the initiation of atherosclerosis
TL;DR: A role for MCP-1 in the development of early atherosclerotic lesions is revealed and upregulation of this chemokine by minimally oxidized lipids is an important link between hyperlipidaemia and fatty streak formation.
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Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
TL;DR: It is demonstrated that chemokine receptors are markers of naive and polarized T cell subsets and suggested that flexible programs of chemokin receptor gene expression may control tissue-specific migration of effector T cells.
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The origin and kinetics of mononuclear phagocytes
Ralph van Furth,Zanvil A. Cohn +1 more
TL;DR: It was concluded that the rapidly dividing mononuclear phagocytes of the bone marrow, called promonocytes, are the progenitor cells of the monocytes and give rise to peritoneal macrophages.
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Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant
TL;DR: MCP-1 is the major lymphocyte chemoattractant secreted by mitogen-stimulated peripheral blood mononuclear cells and is capable of acting as a potent T-lymphocyte, as well as monocyte, chemoATTractant.
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Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells
Susan D. Cushing,Judith A. Berliner,Anthony J. Valente,Mary C. Territo,M Navab,Farhad Parhami,Ross G. Gerrity,Colin J. Schwartz,Alan M. Fogelman +8 more
TL;DR: After exposure to low density lipoprotein (LDL) that had been minimally modified by oxidation (MM-LDL), human endothelial cells (EC) and smooth muscle cells (SMC) cultured separately or together produced 2- to 3-fold more monocyte chemotactic activity than did control cells or cells exposed to freshly isolated LDL.